In vivo analysis of vectors involved in pupil constriction in Chinese subjects with angle closure

Ce Zheng, Carol Y. Cheung, Tin Aung, Arun Narayanaswamy, Sim Heng Ong, David S. Friedman, John C. Allen, Mani Baskaran, Paul T. Chew, Shamira A. Perera

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


PURPOSE: To evaluate the acceleration of pupil constriction (APC) in response to illumination using video anterior segment optical coherence tomography (AS-OCT) in angle closure and normal eyes. METHODS: This was an observational study of 342 Chinese subjects. Iris and angle changes in response to illumination were captured with real-time video recordings of AS-OCT and analyzed frame by frame. APC was calculated using a quadratic function, fitting pupil diameter to a time series. APC was divided into two vector components: acceleration of pupil block (APB) acting perpendicular to the lens surface and acceleration of iris stretch (AIS) acting toward the iris root. RESULTS: Of 342 eligible patients, 306 (89.5%) were available for analysis; of whom 136 (41.7%) had angle closure. After adjusting for age, sex, baseline pupil diameter, and iris thickness, APC was significantly lower in angle closure eyes (0.61 mm/s2) than in open-angle eyes (0.90 mm/s2) (P < 0.0001) as was AIS (0.58 mm/ s2 vs. 0.89 mm/s2) (P < 0.001). APB was significantly higher in angle closure eyes compared to open-angle eyes (0.14 mm/s2 vs. 0.09 mm/s2) (P < 0.001). After adjusting for age and sex in logistic regression, the magnitude and direction of all vector parameters were significantly associated with presence of angle closure. CONCLUSIONS: Angle closure eyes have smaller AIS and larger APB in response to illumination as measured using AS-OCT videography. This shows that, comparatively, the iris of angle closure eyes stretches less and develops a more convex configuration in response to illumination.

Original languageEnglish (US)
Pages (from-to)6756-6762
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number11
StatePublished - Oct 2012

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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