TY - JOUR
T1 - In vitro T cell-mediated killing of Pseudomonas aeruginosa. III. The role of suppressor T cells in nonresponder mice
AU - Powderly, W. G.
AU - Pier, G. B.
AU - Markham, R. B.
PY - 1986
Y1 - 1986
N2 - T lymphocytes from immune BALB/c mice can adoptively transfer protection against infection with the extracellular Gram-negative bacterium Pseudomonas aeruginosa to nonimmune recipients, and in vitro, immune T cells are able to kill these bacteria. Earlier studies indicated that this killing is mediated by a bactericidal lymphokine. The current studies demonstrate that T cells from immunized CB.20 mice, a strain congenic with BALB/c, fail to kill Pseudomonas aeruginosa in vitro. This nonresponsiveness is attributable to the activity of suppressor T cells of the Lyt-1-, 2,3+, I-J+ phenotype. CB.20 mice are known to differ from BALB/c mice only at a single locus, which includes the Igh-1 allotype C(H) genes. These results suggest a critical role for this locus or closely linked genes in the control of T cell killing of this extracellular bacterium.
AB - T lymphocytes from immune BALB/c mice can adoptively transfer protection against infection with the extracellular Gram-negative bacterium Pseudomonas aeruginosa to nonimmune recipients, and in vitro, immune T cells are able to kill these bacteria. Earlier studies indicated that this killing is mediated by a bactericidal lymphokine. The current studies demonstrate that T cells from immunized CB.20 mice, a strain congenic with BALB/c, fail to kill Pseudomonas aeruginosa in vitro. This nonresponsiveness is attributable to the activity of suppressor T cells of the Lyt-1-, 2,3+, I-J+ phenotype. CB.20 mice are known to differ from BALB/c mice only at a single locus, which includes the Igh-1 allotype C(H) genes. These results suggest a critical role for this locus or closely linked genes in the control of T cell killing of this extracellular bacterium.
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M3 - Article
C2 - 2933465
AN - SCOPUS:0022633258
SN - 0022-1767
VL - 136
SP - 299
EP - 303
JO - Journal of Immunology
JF - Journal of Immunology
IS - 1
ER -