In vitro fertilization and embryo transfer (IVF/ET): An established and successful therapy for endometriosis

Sergio Oehninger, anibal A. Acosta, David Kreiner, Suheil J. Muasher, Howard W. Jones, Zev Rosenwaks

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


The purpose of this report is to present a 6-year experience in the management of endometriosis with in vitro fertilization and embryo transfer (IVF/ET). We divided 136 patients who underwent 280 cycles into three groups: (1) previous history of endometriosis but normal pelvis at the time of oocyte retrieval, (2) stages I-II endometriosis (revised AFS classification), and (3) stages III-IV endometriosis. The stimulation protocols, estradiol (E2) responses, and distribution of terminal E2 patterns were similar in all groups. Group 3 had significantly fewer preovulatory and immature oocytes retrieved and fewer embryos transferred. The fertilization rate and the per cycle/per transfer pregnancy rates were similar in all groups. The miscarriage rate was higher in group 3, and the on-going pregnancy rate per cycle was lower, Luteal phase E2 and progesterone levels were comparable in all groups. No differences were found when groups 2 and 3 were analyzed for the presence of one or two ovaries or the presencelabsence of ovarian endometriosis. The overall fertilization rate, the per cycle/per transfer pregnancy rates, and the miscarriage rate were similar to those of tubal factor patients. We underscore the excellent out-come of patients with minimal or mild endometriosis in IVF/ET. We conclude that patients with moderate or severe endometriosis have a compromised reproductive potential, probably because of a reduced oocyte recovery rate and poor embryo quality.

Original languageEnglish (US)
Pages (from-to)249-256
Number of pages8
JournalJournal of In Vitro Fertilization and Embryo Transfer
Issue number5
StatePublished - Oct 1988
Externally publishedYes


  • endometriosis
  • in vitro fertilization
  • infertility

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Obstetrics and Gynecology
  • Developmental Biology


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