In-vitro effect of a diabetic serum factor on the generation of superoxide free radical, it's quenching ability and lysosomal degranulation in normal polymorpho nuclear leucocytes

S. Biswas; A. Bhelwa; A. Ittoop; S. Biswal; N. Nath

doi:10.1007/BF02869575

In-vitro effect of a diabetic serum factor on the generation of superoxide free radical, it's quenching ability and lysosomal degranulation in normal polymorpho nuclear leucocytes

S. Biswas, A. Bhelwa, A. Ittoop, S. Biswal, N. Nath

Research output: Contribution to journal › Article › peer-review

Abstract

Normal polymorpho nuclear leucocytes (PMNL) when assaulted with diabetic serum factor in-vitro, recorded enhanced generation of oxygen free radical, and lysosomal degranulation. It also caused a decrease in the cytosolic superoxide dismutase activity. Time-plot studies revealed PMNL susceptibility to diabetic serum factor for oxidative injury and concomitant decrease in SOD, consequential for lysosomal degranulation.

Original language	English (US)
Pages (from-to)	75-78
Number of pages	4
Journal	Indian Journal of Clinical Biochemistry
Volume	9
Issue number	2
DOIs	https://doi.org/10.1007/BF02869575
State	Published - Dec 1994
Externally published	Yes

Keywords

DSF
O. SOD
PMNL
lysosomal degranulation

ASJC Scopus subject areas

Clinical Biochemistry

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10.1007/BF02869575

Cite this

In-vitro effect of a diabetic serum factor on the generation of superoxide free radical, it's quenching ability and lysosomal degranulation in normal polymorpho nuclear leucocytes. / Biswas, S.; Bhelwa, A.; Ittoop, A. et al.
In: Indian Journal of Clinical Biochemistry, Vol. 9, No. 2, 12.1994, p. 75-78.

Research output: Contribution to journal › Article › peer-review

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AU - Nath, N.

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AB - Normal polymorpho nuclear leucocytes (PMNL) when assaulted with diabetic serum factor in-vitro, recorded enhanced generation of oxygen free radical, and lysosomal degranulation. It also caused a decrease in the cytosolic superoxide dismutase activity. Time-plot studies revealed PMNL susceptibility to diabetic serum factor for oxidative injury and concomitant decrease in SOD, consequential for lysosomal degranulation.

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In-vitro effect of a diabetic serum factor on the generation of superoxide free radical, it's quenching ability and lysosomal degranulation in normal polymorpho nuclear leucocytes

Abstract

Keywords

ASJC Scopus subject areas

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