In situ cartilage engineering by extracellular matrix-biomaterial bonding

D. A. Wang, A. Taboas, J. D. Meyers, C. G. Williams, J. Wenz, R. G.S. Spencer, J. H. Elisseeff

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The design of tissue-initiated photopolymerization, where collagen proteins in the extracellular matrix were used to induce a photo-initiated hydrogen formation with the biomaterial covalently integrated to the cartilage tissue, was investigated. Mesenchymal stem cells (MSC) were encapsulated and transplanted in situ for chondrogenesis. Nuclear magnetic resonance imaging was used to analyze the engineered tissue development by determining the parameters such as tissue integration, degradation rate, and glycosaminoglycan (GAG) content. The biocompatibility testing showed good cell viability both in the cartilage chips and hydrogel explants. The mechanical testing showed that the directed covalent provided a stable biomaterial-tissue interface.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress


OtherTransactions - 7th World Biomaterials Congress

ASJC Scopus subject areas

  • General Engineering


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