In situ cartilage and bone tissue engineering using phosphoester-containing hydrogels

Dong An Wang, Christopher G. Williams, Syuk Jin Lee, Jason D. Meyers, Anya Taboas, Nicholas Cher, Blanka Sharma, Tae Kyun Kim, Richard G.S. Spencer, Jennifer H. Elisseeff

Research output: Contribution to journalConference articlepeer-review


Tissue engineering techniques have developed a minimally invasive strategy to place hydrogel into a defect by macromer injection. Goat mesenchymal stem cells (gMSC) were introduced into a biodegradable phosphoester hydrogel and transplanted into the cartilage defect for 3-dimensional in vitro cultivation until the substitute begins to integrate with the surrounding tissue. Liquid precursor and rapid solidification provided the feasibility for implant-defect steric appropriateness, as well as cell encapsulation. It was concluded that the development of the hydrogel-cartilage transplantation system will be real-timely and non-invasively monitored through nuclear magnetic resonance imaging (MRI).

Original languageEnglish (US)
Article numberF8.14
Pages (from-to)165-167
Number of pages3
JournalMaterials Research Society Symposium Proceedings
Issue number1
StatePublished - 2004
Event2003 MRS Fall Meeting - Boston, MA, United States
Duration: Dec 1 2003Dec 4 2003

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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