In situ cartilage and bone tissue engineering using phosphoester-containing hydrogels

Dong An Wang; Christopher G. Williams; Syuk Jin Lee; Jason D. Meyers; Anya Taboas; Nicholas Cher; Blanka Sharma; Tae Kyun Kim; Richard G.S. Spencer; Jennifer H. Elisseeff

In situ cartilage and bone tissue engineering using phosphoester-containing hydrogels

Dong An Wang, Christopher G. Williams, Syuk Jin Lee, Jason D. Meyers, Anya Taboas, Nicholas Cher, Blanka Sharma, Tae Kyun Kim, Richard G.S. Spencer, Jennifer H. Elisseeff

School of Medicine

Research output: Contribution to journal › Conference article › peer-review

Abstract

Tissue engineering techniques have developed a minimally invasive strategy to place hydrogel into a defect by macromer injection. Goat mesenchymal stem cells (gMSC) were introduced into a biodegradable phosphoester hydrogel and transplanted into the cartilage defect for 3-dimensional in vitro cultivation until the substitute begins to integrate with the surrounding tissue. Liquid precursor and rapid solidification provided the feasibility for implant-defect steric appropriateness, as well as cell encapsulation. It was concluded that the development of the hydrogel-cartilage transplantation system will be real-timely and non-invasively monitored through nuclear magnetic resonance imaging (MRI).

Original language	English (US)
Article number	F8.14
Pages (from-to)	165-167
Number of pages	3
Journal	Materials Research Society Symposium Proceedings
Volume	EXS
Issue number	1
State	Published - 2004
Event	2003 MRS Fall Meeting - Boston, MA, United States Duration: Dec 1 2003 → Dec 4 2003

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "In situ cartilage and bone tissue engineering using phosphoester-containing hydrogels",

abstract = "Tissue engineering techniques have developed a minimally invasive strategy to place hydrogel into a defect by macromer injection. Goat mesenchymal stem cells (gMSC) were introduced into a biodegradable phosphoester hydrogel and transplanted into the cartilage defect for 3-dimensional in vitro cultivation until the substitute begins to integrate with the surrounding tissue. Liquid precursor and rapid solidification provided the feasibility for implant-defect steric appropriateness, as well as cell encapsulation. It was concluded that the development of the hydrogel-cartilage transplantation system will be real-timely and non-invasively monitored through nuclear magnetic resonance imaging (MRI).",

author = "Wang, {Dong An} and Williams, {Christopher G.} and Lee, {Syuk Jin} and Meyers, {Jason D.} and Anya Taboas and Nicholas Cher and Blanka Sharma and Kim, {Tae Kyun} and Spencer, {Richard G.S.} and Elisseeff, {Jennifer H.}",

year = "2004",

language = "English (US)",

volume = "EXS",

pages = "165--167",

journal = "Materials Research Society Symposium Proceedings",

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note = "2003 MRS Fall Meeting ; Conference date: 01-12-2003 Through 04-12-2003",

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TY - JOUR

T1 - In situ cartilage and bone tissue engineering using phosphoester-containing hydrogels

AU - Wang, Dong An

AU - Williams, Christopher G.

AU - Lee, Syuk Jin

AU - Meyers, Jason D.

AU - Taboas, Anya

AU - Cher, Nicholas

AU - Sharma, Blanka

AU - Kim, Tae Kyun

AU - Spencer, Richard G.S.

AU - Elisseeff, Jennifer H.

PY - 2004

Y1 - 2004

N2 - Tissue engineering techniques have developed a minimally invasive strategy to place hydrogel into a defect by macromer injection. Goat mesenchymal stem cells (gMSC) were introduced into a biodegradable phosphoester hydrogel and transplanted into the cartilage defect for 3-dimensional in vitro cultivation until the substitute begins to integrate with the surrounding tissue. Liquid precursor and rapid solidification provided the feasibility for implant-defect steric appropriateness, as well as cell encapsulation. It was concluded that the development of the hydrogel-cartilage transplantation system will be real-timely and non-invasively monitored through nuclear magnetic resonance imaging (MRI).

AB - Tissue engineering techniques have developed a minimally invasive strategy to place hydrogel into a defect by macromer injection. Goat mesenchymal stem cells (gMSC) were introduced into a biodegradable phosphoester hydrogel and transplanted into the cartilage defect for 3-dimensional in vitro cultivation until the substitute begins to integrate with the surrounding tissue. Liquid precursor and rapid solidification provided the feasibility for implant-defect steric appropriateness, as well as cell encapsulation. It was concluded that the development of the hydrogel-cartilage transplantation system will be real-timely and non-invasively monitored through nuclear magnetic resonance imaging (MRI).

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M3 - Conference article

AN - SCOPUS:23844558804

SN - 0272-9172

VL - EXS

SP - 165

EP - 167

JO - Materials Research Society Symposium Proceedings

JF - Materials Research Society Symposium Proceedings

IS - 1

M1 - F8.14

T2 - 2003 MRS Fall Meeting

Y2 - 1 December 2003 through 4 December 2003

ER -

In situ cartilage and bone tissue engineering using phosphoester-containing hydrogels

Abstract

ASJC Scopus subject areas

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