TY - JOUR
T1 - In Elimination Settings, Measles Antibodies Wane After Vaccination but Not After Infection
T2 - A Systematic Review and Meta-Analysis
AU - Bolotin, Shelly
AU - Osman, Selma
AU - Hughes, Stephanie L.
AU - Ariyarajah, Archchun
AU - Tricco, Andrea C.
AU - Khan, Sumaiya
AU - Li, Lennon
AU - Johnson, Caitlin
AU - Friedman, Lindsay
AU - Gul, Nazish
AU - Jardine, Rachel
AU - Faulkner, Maryrose
AU - Hahné, Susan J.M.
AU - Heffernan, Jane M.
AU - Dabbagh, Alya
AU - Rota, Paul A.
AU - Severini, Alberto
AU - Jit, Mark
AU - Durrheim, David N.
AU - Orenstein, Walter A.
AU - Moss, William J.
AU - Funk, Sebastian
AU - Turner, Nikki
AU - Schluter, William
AU - Jawad, Jaleela S.
AU - Crowcroft, Natasha S.
N1 - Publisher Copyright:
© 2022 Her Majesty the Queen in Right of Canada, as represented by the Public Health Ontario,.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Background: We conducted a systematic review to assess whether measles humoral immunity wanes in previously infected or vaccinated populations in measles elimination settings. Methods: After screening 16 822 citations, we identified 9 articles from populations exposed to wild-type measles and 16 articles from vaccinated populations that met our inclusion criteria. Results: Using linear regression, we found that geometric mean titers (GMTs) decreased significantly in individuals who received 2 doses of measles-containing vaccine (MCV) by 121.8 mIU/mL (95% confidence interval [CI], -212.4 to -31.1) per year since vaccination over 1 to 5 years, 53.7 mIU/mL (95% CI, -95.3 to -12.2) 5 to 10 years, 33.2 mIU/mL (95% CI, -62.6 to -3.9), 10 to 15 years, and 24.1 mIU/mL (95% CI, -51.5 to 3.3) 15 to 20 years since vaccination. Decreases in GMT over time were not significant after 1 dose of MCV or after infection. Decreases in the proportion of seropositive individuals over time were not significant after 1 or 2 doses of MCV or after infection. Conclusions: Measles antibody waning in vaccinated populations should be considered in planning for measles elimination.
AB - Background: We conducted a systematic review to assess whether measles humoral immunity wanes in previously infected or vaccinated populations in measles elimination settings. Methods: After screening 16 822 citations, we identified 9 articles from populations exposed to wild-type measles and 16 articles from vaccinated populations that met our inclusion criteria. Results: Using linear regression, we found that geometric mean titers (GMTs) decreased significantly in individuals who received 2 doses of measles-containing vaccine (MCV) by 121.8 mIU/mL (95% confidence interval [CI], -212.4 to -31.1) per year since vaccination over 1 to 5 years, 53.7 mIU/mL (95% CI, -95.3 to -12.2) 5 to 10 years, 33.2 mIU/mL (95% CI, -62.6 to -3.9), 10 to 15 years, and 24.1 mIU/mL (95% CI, -51.5 to 3.3) 15 to 20 years since vaccination. Decreases in GMT over time were not significant after 1 dose of MCV or after infection. Decreases in the proportion of seropositive individuals over time were not significant after 1 or 2 doses of MCV or after infection. Conclusions: Measles antibody waning in vaccinated populations should be considered in planning for measles elimination.
KW - measles elimination
KW - measles immunity
KW - measles vaccination
KW - waning immunity
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U2 - 10.1093/infdis/jiac039
DO - 10.1093/infdis/jiac039
M3 - Review article
C2 - 35417025
AN - SCOPUS:85139376031
SN - 0022-1899
VL - 226
SP - 1127
EP - 1139
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -