TY - JOUR
T1 - Improving the therapeutic ratio of external beam irradiation for carcinoma of the prostate
AU - Forman, Jeffrey D.
AU - Zinreich, Eva
AU - Lee, Ding Jen
AU - Wharam, Moody D.
AU - Baumgardner, Rosemary A.
AU - Order, Stanley E.
PY - 1985/12
Y1 - 1985/12
N2 - From 1975 to 1983, 240 patients with carcinoma of the prostate, Stages A2 to C, were treated with whole pelvic radiation followed by a 2-week rest and then a reduced field of radiation. The reduced prostatic field was evaluated for adequacy of tumor coverage by CT scan or ultrasound. The local regional control rate was 94%, with a 5-year actuarial survival for all stages of 72%. Severe complications occurred in 3% of patients and moderate complications in 13%. Two major factors that were identified as contributing to the risk of complications included previous or subsequent surgical intervention. Our technique of external beam radiotherapy resulted in a favorable therapeutic ratio, that is, excellent local-regional control with minimal morbidity.
AB - From 1975 to 1983, 240 patients with carcinoma of the prostate, Stages A2 to C, were treated with whole pelvic radiation followed by a 2-week rest and then a reduced field of radiation. The reduced prostatic field was evaluated for adequacy of tumor coverage by CT scan or ultrasound. The local regional control rate was 94%, with a 5-year actuarial survival for all stages of 72%. Severe complications occurred in 3% of patients and moderate complications in 13%. Two major factors that were identified as contributing to the risk of complications included previous or subsequent surgical intervention. Our technique of external beam radiotherapy resulted in a favorable therapeutic ratio, that is, excellent local-regional control with minimal morbidity.
KW - Carcinoma of the prostate
KW - External beam irradiation
KW - Therapeutic ratio
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U2 - 10.1016/0360-3016(85)90086-0
DO - 10.1016/0360-3016(85)90086-0
M3 - Article
C2 - 4066439
AN - SCOPUS:0022347067
SN - 0360-3016
VL - 11
SP - 2073
EP - 2080
JO - International journal of radiation oncology, biology, physics
JF - International journal of radiation oncology, biology, physics
IS - 12
ER -