Improving pandemic influenza risk assessment

Colin A. Russell; Peter M. Kasson; Ruben O. Donis; Steven Riley; John Dunbar; Andrew Rambaut; Jason Asher; Stephen Burke; C. Todd Davis; Rebecca J. Garten; Sandrasegaram Gnanakaran; Simon I. Hay; Sander Herfst; Nicola S. Lewis; James O. Lloyd-Smith; Catherine A. Macken; Sebastian Maurer-Stroh; Elizabeth Neuhaus; Colin R. Parrish; Kim M. Pepin; Samuel S. Shepard; David L. Smith; David L. Suarez; Susan C. Trock; Marc Alain Widdowson; Dylan B. George; Marc Lipsitch; Jesse D. Bloom

doi:10.7554/eLife.03883

Improving pandemic influenza risk assessment

Colin A. Russell, Peter M. Kasson, Ruben O. Donis, Steven Riley, John Dunbar, Andrew Rambaut, Jason Asher, Stephen Burke, C. Todd Davis, Rebecca J. Garten, Sandrasegaram Gnanakaran, Simon I. Hay, Sander Herfst, Nicola S. Lewis, James O. Lloyd-Smith, Catherine A. Macken, Sebastian Maurer-Stroh, Elizabeth Neuhaus, Colin R. Parrish, Kim M. PepinSamuel S. Shepard, David L. Smith, David L. Suarez, Susan C. Trock, Marc Alain Widdowson, Dylan B. George, Marc Lipsitch, Jesse D. Bloom

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Assessing the pandemic risk posed by specific non-human influenza A viruses is an important goal in public health research. As influenza virus genome sequencing becomes cheaper, faster, and more readily available, the ability to predict pandemic potential from sequence data could transform pandemic influenza risk assessment capabilities. However, the complexities of the relationships between virus genotype and phenotype make such predictions extremely difficult. The integration of experimental work, computational tool development, and analysis of evolutionary pathways, together with refinements to influenza surveillance, has the potential to transform our ability to assess the risks posed to humans by non-human influenza viruses and lead to improved pandemic preparedness and response.

Original language	English (US)
Article number	e03883
Pages (from-to)	e03883
Journal	eLife
Volume	3
DOIs	https://doi.org/10.7554/eLife.03883
State	Published - 2014

Keywords

emergence
evolutionary biology
genomics
human
infectious disease
influenza
microbiology
pandemic
viruses

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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10.7554/eLife.03883

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Russell, C. A., Kasson, P. M., Donis, R. O., Riley, S., Dunbar, J., Rambaut, A., Asher, J., Burke, S., Davis, C. T., Garten, R. J., Gnanakaran, S., Hay, S. I., Herfst, S., Lewis, N. S., Lloyd-Smith, J. O., Macken, C. A., Maurer-Stroh, S., Neuhaus, E., Parrish, C. R., ... Bloom, J. D. (2014). Improving pandemic influenza risk assessment. eLife, 3, e03883. Article e03883. https://doi.org/10.7554/eLife.03883

Russell, CA, Kasson, PM, Donis, RO, Riley, S, Dunbar, J, Rambaut, A, Asher, J, Burke, S, Davis, CT, Garten, RJ, Gnanakaran, S, Hay, SI, Herfst, S, Lewis, NS, Lloyd-Smith, JO, Macken, CA, Maurer-Stroh, S, Neuhaus, E, Parrish, CR, Pepin, KM, Shepard, SS, Smith, DL, Suarez, DL, Trock, SC, Widdowson, MA, George, DB, Lipsitch, M & Bloom, JD 2014, 'Improving pandemic influenza risk assessment', eLife, vol. 3, e03883, pp. e03883. https://doi.org/10.7554/eLife.03883

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abstract = "Assessing the pandemic risk posed by specific non-human influenza A viruses is an important goal in public health research. As influenza virus genome sequencing becomes cheaper, faster, and more readily available, the ability to predict pandemic potential from sequence data could transform pandemic influenza risk assessment capabilities. However, the complexities of the relationships between virus genotype and phenotype make such predictions extremely difficult. The integration of experimental work, computational tool development, and analysis of evolutionary pathways, together with refinements to influenza surveillance, has the potential to transform our ability to assess the risks posed to humans by non-human influenza viruses and lead to improved pandemic preparedness and response. ",

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AU - Neuhaus, Elizabeth

AU - Parrish, Colin R.

AU - Pepin, Kim M.

AU - Shepard, Samuel S.

AU - Smith, David L.

AU - Suarez, David L.

AU - Trock, Susan C.

AU - Widdowson, Marc Alain

AU - George, Dylan B.

AU - Lipsitch, Marc

AU - Bloom, Jesse D.

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Improving pandemic influenza risk assessment

Abstract

Keywords

ASJC Scopus subject areas

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