Improving Detection of Cancer Predisposition Syndromes in Pediatric Oncology

Jasmine Knoll, Ashley Li, Christy H. Smith, Kristen Schratz, Stacy L. Cooper, Tarek Meah, Elizabeth Helmke, Christine A. Pratilas, Joann Bodurtha

Research output: Contribution to journalArticlepeer-review


Implementation and adherence to consensus statement criteria for referral of pediatric cancer patients for genetic evaluation are critical to identify the 5% to 10% with a genetic cancer predisposition syndrome. The authors implemented a Plan-Do-Study-Act quality improvement initiative aimed at increasing referrals of at-risk patients. Retrospective chart review was followed by educational intervention - with impact assessed over a 9-month prospective chart review. Referral rate improved >2-fold and there was an improvement in documented oncologic history to at least a third-degree relative. The integration of quality improvement can be an effective tool to improve the referral of patients with an elevated risk for a cancer predisposition syndrome.

Original languageEnglish (US)
Pages (from-to)E891-E896
JournalJournal of Pediatric Hematology/Oncology
Issue number6
StatePublished - Aug 2021


  • cancer predisposition syndromes
  • family history
  • germline testing
  • oncologic genetics
  • quality improvement

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health


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