Improvement in naltrexone treatment compliance with contingency management

Kenzie L. Preston, Kenneth Silverman, Annie Umbricht, Anna Dejesus, Ivan D. Montoya, Charles R. Schuster

Research output: Contribution to journalArticlepeer-review

128 Scopus citations


The efficacy of a voucher-based incentive program for improving adherence to outpatient, thrice weekly naltrexone maintenance was tested in a three group, randomized, 12-week clinical trial. Voucher incentives were given as follows: contingent group (n=19) for each consecutive naltrexone dose ingested; non-contingent group (n=19) on unpredictable schedule independently of taking naltrexone; no-voucher group (n=20) none. Vouchers were exchangeable for goods and services. The contingent group had significantly longer treatment retention and ingested significantly more doses of naltrexone (consecutive and total) than either control group. Voucher incentives can significantly increase adherence to naltrexone maintenance in recently detoxified opioid dependent individuals. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)127-135
Number of pages9
JournalDrug and alcohol dependence
Issue number2
StatePublished - Apr 1 1999


  • Contingency management
  • Naltrexone
  • Opioid-dependence
  • Treatment
  • Treatment compliance

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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