Improved therapeutic monitoring with several interventions: A randomized trial

Adrianne C. Feldstein, David H. Smith, Nancy Perrin, Xiuhai Yang, Mary Rix, Marsha A. Raebel, David J. Magid, Steven R. Simon, Stephen B. Soumerai

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Background: Medication errors are frequently related to failure to appropriately select medications or adjust for laboratory parameters. Differences between guideline recommendations and actual frequency of therapeutic laboratory monitoring are substantial. This study evaluated interventions to improve laboratory monitoring at initiation of medication therapy. Methods: This cluster-randomized trial compared 3 interventions to usual care for 10 medications in 15 primary care clinics in a health maintenance organization with an electronic medical record system. Eligible patients, identified from electronic databases, had not received recommended laboratory monitoring within 5 days after new dispensing of a study medication. Interventions were an electronic medical record reminder to the prescribing health care professional, an automated voice message to the patient, and a pharmacy team outreach to the patient. Primary outcome was completion of all recommended baseline laboratory monitoring. Results: A total of 961 patients participated in the study. At 25 days, 95 (48.5%) of 196 patients in the electronic medical record reminder group, 177 (66.3%) of 267 in the automated voice message group, 214 (82.0%) of 261 in the pharmacy team outreach group, and 53 (22.4%) of 237 in the usual care group had completed all recommended baseline laboratory monitoring (P<.001). After adjustments, the hazard ratios for completing laboratory monitoring compared with usual care were 2.5 (95% confidence interval, 1.8-3.5) for electronic medical record reminder, 4.1 (95% confidence interval, 3.0-5.6) for automated voice message, and 6.7 (95% confidence interval, 4.9-9.0) for pharmacy team outreach. Conclusions: All 3 interventions were effective in increasing laboratory monitoring when initiating new medications in primary care. Further work is necessary to determine if these interventions improve patient outcomes. Trial Registration: Identifier: NCT00256386.

Original languageEnglish (US)
Pages (from-to)1848-1854
Number of pages7
JournalArchives of internal medicine
Issue number17
StatePublished - Sep 25 2006
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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