Importance of risk factors in the angiographic progression of coronary artery disease

Joel S. Raichlen, Bernadine Healy, Stephen C. Achuff, Thomas A. Pearson

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Although specific risk factors correlate with the development of clinical coronary events, little Is known about their Importance in patients with established coronary artery disease (CAD). A numerical scaring system was used to assess serial coronary anglograms in subjects who had detailed risk factor determinations. Strong linear correlations were demonstrated between the extent of progression of CAD and diastolic blood pressure (BP) (p = 0.002), systolic BP (p = 0.094), the number of cigarette pack-years smoked among current smokers (p = 0.022), fasting blood glucose level (p = 0.017) and low levels of physical activity at leisure (p = 0.097). This analysis of sequential coronary anglograms identifies SP, cigarette smoking, diabetes mellitus and physical activity as important risk factors in the progression of CAD. These variables merit attention in the management of patients with symptomatic CAD and in secondary coronary prevention trials investigating risk factor modification.

Original languageEnglish (US)
Pages (from-to)66-70
Number of pages5
JournalThe American journal of cardiology
Issue number1
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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