Abstract
Background: J-difference-edited 1H-MR spectra require modeling to quantify signals of low-concentration metabolites. Two main approaches are used for this spectral modeling: simple peak fitting and linear combination modeling (LCM) with a simulated basis set. Recent consensus recommended LCM as the method of choice for the spectral analysis of edited data. Purpose: The aim of this study is to compare the performance of simple peak fitting and LCM in a test-retest dataset, hypothesizing that the more sophisticated LCM approach would improve quantification of Hadamard-edited data compared with simple peak fitting. Methods: A test–retest dataset was re-analyzed using Gannet (simple peak fitting) and Osprey (LCM). These data were obtained from the dorsal anterior cingulate cortex of twelve healthy volunteers, with TE = 80 ms for HERMES and TE = 120 ms for MEGA-PRESS of glutathione (GSH). Within-subject coefficients of variation (CVs) were calculated to quantify between-scan reproducibility of each metabolite estimate. Results: The reproducibility of HERMES GSH estimates was substantially improved using LCM compared to simple peak fitting, from a CV of 19.0–9.9%. For MEGA-PRESS GSH data, reproducibility was similar using LCM and simple peak fitting, with CVs of 7.3 and 8.8%. GABA + CVs from HERMES were 16.7 and 15.2%, respectively for the two models. Conclusion: LCM with simulated basis functions substantially improved the reproducibility of GSH quantification for HERMES data.
Original language | English (US) |
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Article number | 872403 |
Journal | Frontiers in Psychiatry |
Volume | 13 |
DOIs | |
State | Published - Apr 25 2022 |
Keywords
- Gannet
- Gaussian
- Hadamard-edited MRS
- Osprey
- glutathione (GSH)
- linear combination modeling
- γ-aminobutyric acid (GABA)
ASJC Scopus subject areas
- Psychiatry and Mental health