TY - JOUR
T1 - Implications of irradiating the subventricular zone stem cell niche
AU - Capilla-Gonzalez, Vivian
AU - Bonsu, Janice M.
AU - Redmond, Kristin J.
AU - Garcia-Verdugo, Jose Manuel
AU - Quiñones-Hinojosa, Alfredo
N1 - Funding Information:
Dr. Redmond is a member of a research consortium funded by Elekta AB.
Funding Information:
This research was supported by the National Institutes of Health — RO1 NS070024 (AQH), the Instituto de Salud Carlos III — RD12/0019/0028 (VCG), and the Fundación Progreso y Salud of the Andalusian Regional Ministry of Health — PI01092014 (VCG).
Publisher Copyright:
© 2016.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Radiation therapy is a standard treatment for brain tumor patients. However, it comes with side effects, such as neurological deficits. While likely multi-factorial, the effect may in part be associated with the impact of radiation on the neurogenic niches. In the adult mammalian brain, the neurogenic niches are localized in the subventricular zone (SVZ) of the lateral ventricles and the dentate gyrus of the hippocampus, where the neural stem cells (NSCs) reside. Several reports showed that radiation produces a drastic decrease in the proliferative capacity of these regions, which is related to functional decline. In particular, radiation to the SVZ led to a reduced long-term olfactory memory and a reduced capacity to respond to brain damage in animal models, as well as compromised tumor outcomes in patients. By contrast, other studies in humans suggested that increased radiation dose to the SVZ may be associated with longer progression-free survival in patients with high-grade glioma. In this review, we summarize the cellular and functional effects of irradiating the SVZ niche. In particular, we review the pros and cons of using radiation during brain tumor treatment, discussing the complex relationship between radiation dose to the SVZ and both tumor control and toxicity.
AB - Radiation therapy is a standard treatment for brain tumor patients. However, it comes with side effects, such as neurological deficits. While likely multi-factorial, the effect may in part be associated with the impact of radiation on the neurogenic niches. In the adult mammalian brain, the neurogenic niches are localized in the subventricular zone (SVZ) of the lateral ventricles and the dentate gyrus of the hippocampus, where the neural stem cells (NSCs) reside. Several reports showed that radiation produces a drastic decrease in the proliferative capacity of these regions, which is related to functional decline. In particular, radiation to the SVZ led to a reduced long-term olfactory memory and a reduced capacity to respond to brain damage in animal models, as well as compromised tumor outcomes in patients. By contrast, other studies in humans suggested that increased radiation dose to the SVZ may be associated with longer progression-free survival in patients with high-grade glioma. In this review, we summarize the cellular and functional effects of irradiating the SVZ niche. In particular, we review the pros and cons of using radiation during brain tumor treatment, discussing the complex relationship between radiation dose to the SVZ and both tumor control and toxicity.
KW - Brain tumor
KW - Neural stem cells
KW - Neurogenesis
KW - Radiation
KW - Subventricular zone
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U2 - 10.1016/j.scr.2016.02.031
DO - 10.1016/j.scr.2016.02.031
M3 - Review article
C2 - 26921873
AN - SCOPUS:84958984947
SN - 1873-5061
VL - 16
SP - 387
EP - 396
JO - Stem Cell Research
JF - Stem Cell Research
IS - 2
ER -