Implantable gastric stimulation inhibits gastric motility via sympathetic pathway in dogs

Hongbing Zhu, Jiande D.Z. Chen

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Background: The aim of this study was to investigate the effect of implantable gastric stimulation (IGS) on gastric antral contractions and the involvement of the sympathetic pathway. Methods: The study was performed in 5 postprandial sessions in 8 dogs chronically implanted with stimulation electrodes and a gastric cannula: a) IGS via lesser curvature; b) IGS via antrum; c) and d) same as a) and b) but IGS initiated 1 hr before the meal; e) same as a) but with guanethidine. Results: It was found that: 1) IGS significantly inhibited postprandial antral contractions assessed by manometry, and no significant difference was noted in the effect between the two stimulation sites; 2) IGS initiated 1 hr before the meal was more potent than that initiated 30 minutes after the meal; 3) the inhibitory effect of IGS on postprandial antral motility was completely blocked by guanethidine. Conclusion: Acute IGS inhibits postprandial antral contractions, and this inhibitory effect is mediated via the sympathetic pathway.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalObesity Surgery
Issue number1
StatePublished - Jan 2005
Externally publishedYes


  • Gastric electrical stimulation
  • Gastric motility
  • Gastric pacing
  • Implantable gastric stimulator
  • Obesity

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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