@article{63a00d4f724e4346ba919829007d73d2,
title = "Impedance spectroscopic detection of binding and reactions in acid-labile dielectric polymers for biosensor applications",
abstract = "We synthesized previously unreported copolymers with cleavable acid-labile side chains for use as electrochemical sensing layers in order to demonstrate a novel architecture for a one-step immunosensor. This one-step system is in contrast to most antigen-capture signal amplification methods that involve complicated secondary labeling techniques, or require the addition of redox probes to achieve a sensing response. A series of novel copolymers composed of various trityl-containing monomers were synthesized and characterized to determine their dielectric properties. The results indicate that the thin films of these polymers are stable in water, but some begin to degrade under acidic conditions or upon antigen binding, causing observable changes in the phase angle.",
author = "Jennifer Dailey and Michelangelo Fichera and Ellen Silbergeld and Katz, {Howard E.}",
note = "Funding Information: This work was principally funded by NIH R21 grant number R21-EB018426. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. JD is grateful for additional funding through the Center for a Livable Future-Lerner Fellowship and the NSF Graduate Research Fellowship DGE-1232825. We additionally acknowledge funding through a technology transfer grant from the JHU School of Public Health in collaboration with Prof. Ellen Silbergeld. We thank Daniele Madrioli for help with understanding the biological aspects of this work. We gratefully acknowledge Pengfei Zhang for assisting with fluorescence microscopy. Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",
year = "2018",
doi = "10.1039/c7tb03171h",
language = "English (US)",
volume = "6",
pages = "2972--2981",
journal = "Journal of Materials Chemistry B",
issn = "2050-7518",
publisher = "Royal Society of Chemistry",
number = "19",
}