Impedance in the evaluation of the esophagus

Peter I. Wu, Joshua A. Sloan, Shiko Kuribayashi, Hans Gregersen

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The aim of this paper is to review esophageal electrical impedance technologies and to discuss the use of these technologies for physiological measurements, diagnostics, and therapy of esophageal disease. In order to develop a better understanding of the pathophysiology of and improve the diagnosis of esophageal disorders, such as gastroesophageal reflux disease (GERD) and achalasia, several new diagnostic tests, including intraluminal impedance, esophageal mucosal impedance, and the functional luminal imaging probe, have been developed. These technologies have proven valuable for assessment of the esophagus in recent years. They provide information on esophageal flow properties, mucosal integrity, lumen shape, and distensibility in esophageal disorders, in particular for GERD and achalasia. Despite their promise and novel clinical studies, the potential of these technologies has been far from realized. New multidisciplinary approaches will contribute to our understanding and interpretation of esophageal impedance data and disease mechanisms.

Original languageEnglish (US)
Pages (from-to)139-153
Number of pages15
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Nov 10 2020


  • GERD
  • achalasia
  • esophagus
  • functional lumen imaging probe
  • impedance planimetry
  • mucosal impedance

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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