Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging

Madhav Thambisetty; Lori L. Beason-Held; Yang An; Michael Kraut; Jeffrey Metter; Josephine Egan; Luigi Ferrucci; Richard O'Brien; Susan M. Resnick

doi:10.1016/j.neurobiolaging.2013.03.025

Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging

Madhav Thambisetty, Lori L. Beason-Held, Yang An, Michael Kraut, Jeffrey Metter, Josephine Egan, Luigi Ferrucci, Richard O'Brien, Susan M. Resnick

School of Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We investigated whether individuals with impaired glucose tolerance (IGT) in midlife subsequently show regionally specific longitudinal changes in regional cerebral blood flow (rCBF) relative to those with normal glucose tolerance (NGT). Sixty-four cognitively normal participants in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging underwent serial ¹⁵O-water positron emission tomography scans (age at first scan, 69.6 ± 7.5 years) and oral glucose tolerance tests 12 years earlier (age at first oral glucose tolerance test, 57.2 ± 11.1 years). Using voxel-based analysis, we compared changes in rCBF over an 8-year period between 15 participants with IGT in midlife and 49 with NGT. Significant differences were observed in longitudinal change in rCBF between the IGT and NGT groups. The predominant pattern was greater rCBF decline in the IGT group in the frontal, parietal, and temporal cortices. Some brain regions in the frontal and temporal cortices also showed greater longitudinal increments in rCBF in the IGT group. Our findings suggest that IGT in midlife is associated with subsequent longitudinal changes in brain function during aging even in cognitively normal older individuals.

Original language	English (US)
Pages (from-to)	2271-2276
Number of pages	6
Journal	Neurobiology of aging
Volume	34
Issue number	10
DOIs	https://doi.org/10.1016/j.neurobiolaging.2013.03.025
State	Published - Oct 2013

Keywords

Aging
Alzheimer's
Brain function
Cerebral blood flow
Impaired glucose tolerance
Insulin resistance
PET

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2013.03.025

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title = "Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging",

abstract = "We investigated whether individuals with impaired glucose tolerance (IGT) in midlife subsequently show regionally specific longitudinal changes in regional cerebral blood flow (rCBF) relative to those with normal glucose tolerance (NGT). Sixty-four cognitively normal participants in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging underwent serial 15O-water positron emission tomography scans (age at first scan, 69.6 ± 7.5 years) and oral glucose tolerance tests 12 years earlier (age at first oral glucose tolerance test, 57.2 ± 11.1 years). Using voxel-based analysis, we compared changes in rCBF over an 8-year period between 15 participants with IGT in midlife and 49 with NGT. Significant differences were observed in longitudinal change in rCBF between the IGT and NGT groups. The predominant pattern was greater rCBF decline in the IGT group in the frontal, parietal, and temporal cortices. Some brain regions in the frontal and temporal cortices also showed greater longitudinal increments in rCBF in the IGT group. Our findings suggest that IGT in midlife is associated with subsequent longitudinal changes in brain function during aging even in cognitively normal older individuals.",

keywords = "Aging, Alzheimer's, Brain function, Cerebral blood flow, Impaired glucose tolerance, Insulin resistance, PET",

author = "Madhav Thambisetty and Beason-Held, {Lori L.} and Yang An and Michael Kraut and Jeffrey Metter and Josephine Egan and Luigi Ferrucci and Richard O'Brien and Resnick, {Susan M.}",

note = "Funding Information: We are grateful to the BLSA participants and neuroimaging staff for their dedication to these studies and the staff of the Johns Hopkins University PET facility for their assistance. This work was supported in part by research and development contract N01-AG-3-2124 from the Intramural Research Program , National Institute on Aging, National Institutes of Health.",

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doi = "10.1016/j.neurobiolaging.2013.03.025",

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AU - Thambisetty, Madhav

AU - Beason-Held, Lori L.

AU - An, Yang

AU - Kraut, Michael

AU - Metter, Jeffrey

AU - Egan, Josephine

AU - Ferrucci, Luigi

AU - O'Brien, Richard

AU - Resnick, Susan M.

N1 - Funding Information: We are grateful to the BLSA participants and neuroimaging staff for their dedication to these studies and the staff of the Johns Hopkins University PET facility for their assistance. This work was supported in part by research and development contract N01-AG-3-2124 from the Intramural Research Program , National Institute on Aging, National Institutes of Health.

PY - 2013/10

Y1 - 2013/10

N2 - We investigated whether individuals with impaired glucose tolerance (IGT) in midlife subsequently show regionally specific longitudinal changes in regional cerebral blood flow (rCBF) relative to those with normal glucose tolerance (NGT). Sixty-four cognitively normal participants in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging underwent serial 15O-water positron emission tomography scans (age at first scan, 69.6 ± 7.5 years) and oral glucose tolerance tests 12 years earlier (age at first oral glucose tolerance test, 57.2 ± 11.1 years). Using voxel-based analysis, we compared changes in rCBF over an 8-year period between 15 participants with IGT in midlife and 49 with NGT. Significant differences were observed in longitudinal change in rCBF between the IGT and NGT groups. The predominant pattern was greater rCBF decline in the IGT group in the frontal, parietal, and temporal cortices. Some brain regions in the frontal and temporal cortices also showed greater longitudinal increments in rCBF in the IGT group. Our findings suggest that IGT in midlife is associated with subsequent longitudinal changes in brain function during aging even in cognitively normal older individuals.

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KW - Aging

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KW - Brain function

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KW - Insulin resistance

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Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging

Abstract

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