Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging

Madhav Thambisetty, Lori L. Beason-Held, Yang An, Michael Kraut, Jeffrey Metter, Josephine Egan, Luigi Ferrucci, Richard O'Brien, Susan M. Resnick

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


We investigated whether individuals with impaired glucose tolerance (IGT) in midlife subsequently show regionally specific longitudinal changes in regional cerebral blood flow (rCBF) relative to those with normal glucose tolerance (NGT). Sixty-four cognitively normal participants in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging underwent serial 15O-water positron emission tomography scans (age at first scan, 69.6 ± 7.5 years) and oral glucose tolerance tests 12 years earlier (age at first oral glucose tolerance test, 57.2 ± 11.1 years). Using voxel-based analysis, we compared changes in rCBF over an 8-year period between 15 participants with IGT in midlife and 49 with NGT. Significant differences were observed in longitudinal change in rCBF between the IGT and NGT groups. The predominant pattern was greater rCBF decline in the IGT group in the frontal, parietal, and temporal cortices. Some brain regions in the frontal and temporal cortices also showed greater longitudinal increments in rCBF in the IGT group. Our findings suggest that IGT in midlife is associated with subsequent longitudinal changes in brain function during aging even in cognitively normal older individuals.

Original languageEnglish (US)
Pages (from-to)2271-2276
Number of pages6
JournalNeurobiology of aging
Issue number10
StatePublished - Oct 2013


  • Aging
  • Alzheimer's
  • Brain function
  • Cerebral blood flow
  • Impaired glucose tolerance
  • Insulin resistance
  • PET

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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