Impaired Down-Regulation of Pituitary Dopamine Receptors by Estradiol in Aged Rats

Kazimierz Kochman; James A. Joseph; Marc R. Blackman; Carole A. Stagg; George S. Roth

doi:10.3181/00379727-192-42949

Impaired Down-Regulation of Pituitary Dopamine Receptors by Estradiol in Aged Rats

Kazimierz Kochman, James A. Joseph, Marc R. Blackman, Carole A. Stagg, George S. Roth

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Administration of 17β-estradiol to mature (6–12 months) rats results in a more than 50% reduction in pituitary dopamine receptor concentrations, without affecting binding affinity. In contrast, when the same manipulation is performed on senescent (24–25 months) rats, negligible change in receptor concentration occurs. These results suggest that age-related increases in estrogen-stimulated prolactin release are not due to decreased dopaminergic inhibition at the receptor level.

Original language	English (US)
Pages (from-to)	23-26
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	192
Issue number	1
DOIs	https://doi.org/10.3181/00379727-192-42949
State	Published - Oct 1989

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Administration of 17β-estradiol to mature (6–12 months) rats results in a more than 50% reduction in pituitary dopamine receptor concentrations, without affecting binding affinity. In contrast, when the same manipulation is performed on senescent (24–25 months) rats, negligible change in receptor concentration occurs. These results suggest that age-related increases in estrogen-stimulated prolactin release are not due to decreased dopaminergic inhibition at the receptor level.",

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Impaired Down-Regulation of Pituitary Dopamine Receptors by Estradiol in Aged Rats

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