Impact of valve surgery on serum osteopontin levels in patients with mitral regurgitation

H. M. Gunes, G. B. Guler, E. Guler, G. G. Demir, S. Hatipoglu, R. Zehir, F. Kizilirmak, O. Karaca, A. M. Esen, I. Barutcu, M. M. Turkmen, M. M. Can, Victor L. Serebruany

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: Osteopontin (OPN), a sialoprotein present within atherosclerotic lesions, especially in calcified plaques, is linked to the progression of coronary artery disease and heart failure. We assessed the impact of valve surgery on serum OPN and left ventricular (LV) function in patients with mitral regurgitation (MR). Methods: Thirty-two patients with severe MR scheduled for surgery were included in the study. Echocardiography markers were assessed preoperatively and at 3 months following the surgery and matched with the serum OPN levels. Results: Valve surgery was associated with a reduction of the ejection fraction (EF) from 55.2 ± 6.3 to 48.8 ± 7.1% after surgery, p <0.001. Following surgery, the OPN level was significantly higher than preoperatively (mean 245, range 36-2,284 ng/ml vs. 76, 6-486 ng/ml, p = 0.007). Preoperative OPN exhibited a slight negative correlation with the EF (r = -0.35, p = 0.04), and a moderate correlation with vena contracta (r = -0.38, p = 0.02). There were no other meaningful correlations between conventional echocardiographic parameters and OPN. Conclusion: Following valve surgery due to severe MR, patients exhibited a decrease in EF and an increase in OPN levels. The assessment of preoperative OPN failed to strongly predict probable LV dysfunction.

Original languageEnglish (US)
Pages (from-to)82-86
Number of pages5
Issue number2
StatePublished - Feb 24 2015


  • Echocardiography
  • Ejection fraction
  • Mitral regurgitation
  • Osteopontin
  • Valve surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)
  • Medicine(all)


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