Impact of trichiasis surgery on physical functioning in Ethiopian patients: Star trial

Meraf A. Wolle; Sandra D. Cassard; Emily W. Gower; Beatriz E. Munoz; Jiangxia Wang; Wondu Alemayehu; Sheila K. West

doi:10.1016/j.ajo.2010.10.039

Impact of trichiasis surgery on physical functioning in Ethiopian patients: Star trial

Meraf A. Wolle, Sandra D. Cassard, Emily W. Gower, Beatriz E. Munoz, Jiangxia Wang, Wondu Alemayehu, Sheila K. West

Research output: Contribution to journal › Article › peer-review

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Abstract

Purpose To evaluate the physical functioning of Ethiopian trichiasis surgery patients before and 6 months after surgery. Design Nested cohort study. Methods This study was nested within the Surgery for Trichiasis, Antibiotics to Prevent Recurrence (STAR) clinical trial conducted in Ethiopia. Demographic information, ocular examinations, and physical functioning assessments were collected before and 6 months after surgery. A single score for patients' physical functioning was constructed using Rasch analysis. A multivariate linear regression model was used to determine if change in physical functioning was associated with change in visual acuity. Results Of the 438 participants, 411 (93.8%) had both baseline and follow-up questionnaires. Physical functioning scores at baseline ranged from -6.32 (great difficulty) to +6.01 (no difficulty). The percentage of participants reporting no difficulty in physical functioning increased by 32.6%; the proportion of participants in the mild/no visual impairment category increased by 8.6%. A multivariate linear regression model showed that for every line of vision gained, physical functioning improves significantly (0.09 units; 95% CI: 0.020.16). Conclusions Surgery to correct trichiasis appears to improve patients' physical functioning as measured at 6 months. More effort in promoting trichiasis surgery is essential, not only to prevent corneal blindness, but also to enable improved functioning in daily life.

Original language	English (US)
Pages (from-to)	850-857
Number of pages	8
Journal	American journal of ophthalmology
Volume	151
Issue number	5
DOIs	https://doi.org/10.1016/j.ajo.2010.10.039
State	Published - May 2011

ASJC Scopus subject areas

Ophthalmology

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@article{3770b50dd9024bdcb704fca5c8876441,

title = "Impact of trichiasis surgery on physical functioning in Ethiopian patients: Star trial",

abstract = "Purpose To evaluate the physical functioning of Ethiopian trichiasis surgery patients before and 6 months after surgery. Design Nested cohort study. Methods This study was nested within the Surgery for Trichiasis, Antibiotics to Prevent Recurrence (STAR) clinical trial conducted in Ethiopia. Demographic information, ocular examinations, and physical functioning assessments were collected before and 6 months after surgery. A single score for patients' physical functioning was constructed using Rasch analysis. A multivariate linear regression model was used to determine if change in physical functioning was associated with change in visual acuity. Results Of the 438 participants, 411 (93.8%) had both baseline and follow-up questionnaires. Physical functioning scores at baseline ranged from -6.32 (great difficulty) to +6.01 (no difficulty). The percentage of participants reporting no difficulty in physical functioning increased by 32.6%; the proportion of participants in the mild/no visual impairment category increased by 8.6%. A multivariate linear regression model showed that for every line of vision gained, physical functioning improves significantly (0.09 units; 95% CI: 0.020.16). Conclusions Surgery to correct trichiasis appears to improve patients' physical functioning as measured at 6 months. More effort in promoting trichiasis surgery is essential, not only to prevent corneal blindness, but also to enable improved functioning in daily life.",

author = "Wolle, {Meraf A.} and Cassard, {Sandra D.} and Gower, {Emily W.} and Munoz, {Beatriz E.} and Jiangxia Wang and Wondu Alemayehu and West, {Sheila K.}",

note = "Funding Information: Publication of this article was funded by grant EY13878 and EY01765 from the National Eye Institute , Bethesda, Maryland. Dr West is the recipient of a Senior Scientific Investigator award from Research to Prevent Blindness, New York, New York. Dr Gower is the recipient of an Ernest and Elizabeth Althouse Special Scholars award from Research to Prevent Blindness. The authors indicate no financial conflicts of interest. Involved in design and conduct of the study (E.G., W.A., B.M., S.W.); collection, management, analysis, and interpretation of the data (M.W., S.C., E.G., B.M., J.W., W.A., S.K.); and preparation, review, or approval of the manuscript (M.W., S.C., E.G., B.M., J.W., W.A., S.K.). All procedures and protocols for this study were reviewed and approved by the Johns Hopkins Medicine Institutional Review Board (JHM-IRB) and the Ethiopian Science and Technology Commission (ESTC). Clinical Trial Registration: www.clinicaltrials.gov (Identifier: NCT00347776 ). The authors would like to acknowledge the STAR Clinical Trial team who collected the data and the patients who participated in this study.",

year = "2011",

month = may,

doi = "10.1016/j.ajo.2010.10.039",

language = "English (US)",

volume = "151",

pages = "850--857",

journal = "American journal of ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

number = "5",

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TY - JOUR

T1 - Impact of trichiasis surgery on physical functioning in Ethiopian patients

T2 - Star trial

AU - Wolle, Meraf A.

AU - Cassard, Sandra D.

AU - Gower, Emily W.

AU - Munoz, Beatriz E.

AU - Wang, Jiangxia

AU - Alemayehu, Wondu

AU - West, Sheila K.

N1 - Funding Information: Publication of this article was funded by grant EY13878 and EY01765 from the National Eye Institute , Bethesda, Maryland. Dr West is the recipient of a Senior Scientific Investigator award from Research to Prevent Blindness, New York, New York. Dr Gower is the recipient of an Ernest and Elizabeth Althouse Special Scholars award from Research to Prevent Blindness. The authors indicate no financial conflicts of interest. Involved in design and conduct of the study (E.G., W.A., B.M., S.W.); collection, management, analysis, and interpretation of the data (M.W., S.C., E.G., B.M., J.W., W.A., S.K.); and preparation, review, or approval of the manuscript (M.W., S.C., E.G., B.M., J.W., W.A., S.K.). All procedures and protocols for this study were reviewed and approved by the Johns Hopkins Medicine Institutional Review Board (JHM-IRB) and the Ethiopian Science and Technology Commission (ESTC). Clinical Trial Registration: www.clinicaltrials.gov (Identifier: NCT00347776 ). The authors would like to acknowledge the STAR Clinical Trial team who collected the data and the patients who participated in this study.

PY - 2011/5

Y1 - 2011/5

N2 - Purpose To evaluate the physical functioning of Ethiopian trichiasis surgery patients before and 6 months after surgery. Design Nested cohort study. Methods This study was nested within the Surgery for Trichiasis, Antibiotics to Prevent Recurrence (STAR) clinical trial conducted in Ethiopia. Demographic information, ocular examinations, and physical functioning assessments were collected before and 6 months after surgery. A single score for patients' physical functioning was constructed using Rasch analysis. A multivariate linear regression model was used to determine if change in physical functioning was associated with change in visual acuity. Results Of the 438 participants, 411 (93.8%) had both baseline and follow-up questionnaires. Physical functioning scores at baseline ranged from -6.32 (great difficulty) to +6.01 (no difficulty). The percentage of participants reporting no difficulty in physical functioning increased by 32.6%; the proportion of participants in the mild/no visual impairment category increased by 8.6%. A multivariate linear regression model showed that for every line of vision gained, physical functioning improves significantly (0.09 units; 95% CI: 0.020.16). Conclusions Surgery to correct trichiasis appears to improve patients' physical functioning as measured at 6 months. More effort in promoting trichiasis surgery is essential, not only to prevent corneal blindness, but also to enable improved functioning in daily life.

AB - Purpose To evaluate the physical functioning of Ethiopian trichiasis surgery patients before and 6 months after surgery. Design Nested cohort study. Methods This study was nested within the Surgery for Trichiasis, Antibiotics to Prevent Recurrence (STAR) clinical trial conducted in Ethiopia. Demographic information, ocular examinations, and physical functioning assessments were collected before and 6 months after surgery. A single score for patients' physical functioning was constructed using Rasch analysis. A multivariate linear regression model was used to determine if change in physical functioning was associated with change in visual acuity. Results Of the 438 participants, 411 (93.8%) had both baseline and follow-up questionnaires. Physical functioning scores at baseline ranged from -6.32 (great difficulty) to +6.01 (no difficulty). The percentage of participants reporting no difficulty in physical functioning increased by 32.6%; the proportion of participants in the mild/no visual impairment category increased by 8.6%. A multivariate linear regression model showed that for every line of vision gained, physical functioning improves significantly (0.09 units; 95% CI: 0.020.16). Conclusions Surgery to correct trichiasis appears to improve patients' physical functioning as measured at 6 months. More effort in promoting trichiasis surgery is essential, not only to prevent corneal blindness, but also to enable improved functioning in daily life.

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Impact of trichiasis surgery on physical functioning in Ethiopian patients: Star trial

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