TY - JOUR
T1 - Impact of Surgical Status, Loneliness, and Disability on Interleukin 6, C-Reactive Protein, Cortisol, and Estrogen in Females with Symptomatic Type I Chiari Malformation
AU - Garcia, Monica A.
AU - Li, Xuan
AU - Allen, Philip A.
AU - Delahanty, Douglas L.
AU - Eppelheimer, Maggie S.
AU - Houston, James R.
AU - Johnson, Dawn M.
AU - Loth, Frank
AU - Maleki, Jahangir
AU - Vorster, Sarel
AU - Luciano, Mark G.
N1 - Funding Information:
We would like to thank the Conquer Chiari Foundation for financially supporting this work. Furthermore, we would like to thank all the participants for their time and dedication to the research study; without their efforts, none of this research would have been possible.
Publisher Copyright:
© 2021, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
PY - 2021/12
Y1 - 2021/12
N2 - Chiari malformation type I (CMI) provides an opportunity for examining possible moderators of allostatic load. CMI patients who had (n = 43) and had not (n = 19) undergone decompression surgery completed questionnaires regarding pain, disability, and loneliness, and provided serum samples for IL-6, CRP, estrogen, and free estradiol assays, and saliva samples to assess diurnal cortisol curves. ANOVAs examining surgical status (decompressed versus non-decompressed), loneliness (high vs. low), and disability (high vs. low) as independent variables and biomarker variables as dependent factors found that loneliness was associated with higher levels of cortisol, F(1, 37) = 4.91, p =.04, η2P =.11, and lower levels of estrogen, F(1, 36) = 7.29, p =.01, η2P =.17, but only in decompressed patients. Results highlight the possible impact of loneliness on biological stress responses and the need to intervene to reduce loneliness in patients with symptomatic CMI.
AB - Chiari malformation type I (CMI) provides an opportunity for examining possible moderators of allostatic load. CMI patients who had (n = 43) and had not (n = 19) undergone decompression surgery completed questionnaires regarding pain, disability, and loneliness, and provided serum samples for IL-6, CRP, estrogen, and free estradiol assays, and saliva samples to assess diurnal cortisol curves. ANOVAs examining surgical status (decompressed versus non-decompressed), loneliness (high vs. low), and disability (high vs. low) as independent variables and biomarker variables as dependent factors found that loneliness was associated with higher levels of cortisol, F(1, 37) = 4.91, p =.04, η2P =.11, and lower levels of estrogen, F(1, 36) = 7.29, p =.01, η2P =.17, but only in decompressed patients. Results highlight the possible impact of loneliness on biological stress responses and the need to intervene to reduce loneliness in patients with symptomatic CMI.
KW - C-Reactive Protein
KW - Chiari malformation
KW - Cortisol
KW - Estrogen
KW - Interleukin 6
KW - Loneliness
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U2 - 10.1007/s12311-021-01251-w
DO - 10.1007/s12311-021-01251-w
M3 - Article
C2 - 33677786
AN - SCOPUS:85102303481
SN - 1473-4222
VL - 20
SP - 872
EP - 886
JO - Cerebellum
JF - Cerebellum
IS - 6
ER -