TY - JOUR
T1 - Impact of Stiffer Arteries on the Response to Antihypertensive Treatment
T2 - A Longitudinal Study of the SardiNIA Cohort
AU - Lakatta, Edward G.
AU - AlunniFegatelli, Danilo
AU - Morrell, Christopher H.
AU - Fiorillo, Edoardo
AU - Orru, Marco
AU - Delitala, Alessandro
AU - Marongiu, Michele
AU - Schlessinger, David
AU - Cucca, Francesco
AU - Scuteri, Angelo
N1 - Publisher Copyright:
© 2019 AMDA – The Society for Post-Acute and Long-Term Care Medicine
PY - 2020/6
Y1 - 2020/6
N2 - Objectives: Carotid-femoral pulse wave velocity (PWV), an index of arterial stiffness and a proxy of arterial aging, has been reported to be an independent determinant of cardiovascular health. Whether the effects of antihypertensive treatment vary in the presence of accelerated arterial aging (stiffer artery, ie, PWV >10 m/s) has not been established. We tested this hypothesis in a longitudinal study in a large community-dwelling population. Design: Longitudinal population study with repeated measures. Setting and Participants: Study population consisted of a cohort of 6011 volunteers (2546 men and 3465 women, age range 14-101 years; 15,011 observations over a median follow-up of 6.8 years) participating in the SardiNIA Study. Measures: Repeated measures of PWV, blood pressure (BP), and metabolic risk factors and the antihypertensive medication trajectories of BP and PWV over time were assessed via mixed effects models. Results: Antihypertensive treatment significantly affected the trajectory of BP in both participants with (−0.47 ± 0.20 mmHg/y, P =.02) and participants without stiffer arteries (−0.47 ± 0.07 mmHg/y, P =.001). They also affected the trajectory of PWV in participants with stiffer artery, independent of the BP values. Conclusions and Implications: Antihypertensive treatment is effective in reducing both BP and PWV in older individuals with stiffer arteries.
AB - Objectives: Carotid-femoral pulse wave velocity (PWV), an index of arterial stiffness and a proxy of arterial aging, has been reported to be an independent determinant of cardiovascular health. Whether the effects of antihypertensive treatment vary in the presence of accelerated arterial aging (stiffer artery, ie, PWV >10 m/s) has not been established. We tested this hypothesis in a longitudinal study in a large community-dwelling population. Design: Longitudinal population study with repeated measures. Setting and Participants: Study population consisted of a cohort of 6011 volunteers (2546 men and 3465 women, age range 14-101 years; 15,011 observations over a median follow-up of 6.8 years) participating in the SardiNIA Study. Measures: Repeated measures of PWV, blood pressure (BP), and metabolic risk factors and the antihypertensive medication trajectories of BP and PWV over time were assessed via mixed effects models. Results: Antihypertensive treatment significantly affected the trajectory of BP in both participants with (−0.47 ± 0.20 mmHg/y, P =.02) and participants without stiffer arteries (−0.47 ± 0.07 mmHg/y, P =.001). They also affected the trajectory of PWV in participants with stiffer artery, independent of the BP values. Conclusions and Implications: Antihypertensive treatment is effective in reducing both BP and PWV in older individuals with stiffer arteries.
KW - Antihypertensive treatment
KW - arterial stiffness
KW - longitudinal cohort study
KW - pulse wave velocity
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U2 - 10.1016/j.jamda.2019.11.014
DO - 10.1016/j.jamda.2019.11.014
M3 - Article
C2 - 31884052
AN - SCOPUS:85077009484
SN - 1525-8610
VL - 21
SP - 720
EP - 725
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
IS - 6
ER -