Impact of six-week viral load on mortality in HIV-infected zimbabwean infants

Kuda Mutasa; Robert Ntozini; Andrew Prendergast; Peter Iliff; Sandra Rukobo; Lawrence Hale Moulton; Brian J. Ward; Jean H. Humphrey

doi:10.1097/INF.0b013e318266aac2

Impact of six-week viral load on mortality in HIV-infected zimbabwean infants

Kuda Mutasa, Robert Ntozini, Andrew Prendergast, Peter Iliff, Sandra Rukobo, Lawrence Hale Moulton, Brian J. Ward, Jean H. Humphrey

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Among 453 untreated HIV-infected Zimbabwean infants, 6-week viral load was the only infant factor that independently predicted mortality. Infants with viral load ≥ 1.59 million copies/mL (cohort median) had 3-fold increased mortality through 6 months (hazard ratio 3.07 [95% confidence interval: 2.16, 4.38]; P < 0.001) and 2-fold increased mortality through 12 months (hazard ratio 2.03 [95% confidence interval: 1.41, 2.91]; P < 0.001], compared with infants with viral load below the median.

Original language	English (US)
Pages (from-to)	948-950
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	31
Issue number	9
DOIs	https://doi.org/10.1097/INF.0b013e318266aac2
State	Published - Sep 2012
Externally published	Yes

Keywords

HIV
disease progression
infants
mortality
viral load

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

Access to Document

10.1097/INF.0b013e318266aac2

Cite this

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title = "Impact of six-week viral load on mortality in HIV-infected zimbabwean infants",

abstract = "Among 453 untreated HIV-infected Zimbabwean infants, 6-week viral load was the only infant factor that independently predicted mortality. Infants with viral load ≥ 1.59 million copies/mL (cohort median) had 3-fold increased mortality through 6 months (hazard ratio 3.07 [95% confidence interval: 2.16, 4.38]; P < 0.001) and 2-fold increased mortality through 12 months (hazard ratio 2.03 [95% confidence interval: 1.41, 2.91]; P < 0.001], compared with infants with viral load below the median.",

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AU - Mutasa, Kuda

AU - Ntozini, Robert

AU - Prendergast, Andrew

AU - Iliff, Peter

AU - Rukobo, Sandra

AU - Moulton, Lawrence Hale

AU - Ward, Brian J.

AU - Humphrey, Jean H.

PY - 2012/9

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AB - Among 453 untreated HIV-infected Zimbabwean infants, 6-week viral load was the only infant factor that independently predicted mortality. Infants with viral load ≥ 1.59 million copies/mL (cohort median) had 3-fold increased mortality through 6 months (hazard ratio 3.07 [95% confidence interval: 2.16, 4.38]; P < 0.001) and 2-fold increased mortality through 12 months (hazard ratio 2.03 [95% confidence interval: 1.41, 2.91]; P < 0.001], compared with infants with viral load below the median.

KW - HIV

KW - disease progression

KW - infants

KW - mortality

KW - viral load

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Impact of six-week viral load on mortality in HIV-infected zimbabwean infants

Abstract

Keywords

ASJC Scopus subject areas

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