Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients

Andrew H. Karaba; Weiqiang Zhou; Shuai Li; Tihitina Y. Aytenfisu; Trevor S. Johnston; Olivia Akinde; Yolanda Eby; Aura T. Abedon; Jennifer L. Alejo; Caroline X. Qin; Elizabeth A. Thompson; Jacqueline Garonzik; Joel N. Blankson; Andrea L. Cox; Justin R. Bailey; Sabra L. Klein; Andrew Pekosz; Dorry Segev; Aaron A.R. Tobian; William A. Werbel

doi:10.1093/cid/ciac652

Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients

Andrew H. Karaba, Weiqiang Zhou, Shuai Li, Tihitina Y. Aytenfisu, Trevor S. Johnston, Olivia Akinde, Yolanda Eby, Aura T. Abedon, Jennifer L. Alejo, Caroline X. Qin, Elizabeth A. Thompson, Jacqueline Garonzik, Joel N. Blankson, Andrea L. Cox, Justin R. Bailey, Sabra L. Klein, Andrew Pekosz, Dorry Segev, Aaron A.R. Tobian, William A. Werbel

Research output: Contribution to journal › Article › peer-review

Abstract

Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of preexisting antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in SOTRs.

Original language	English (US)
Pages (from-to)	E495-E498
Journal	Clinical Infectious Diseases
Volume	76
Issue number	3
DOIs	https://doi.org/10.1093/cid/ciac652
State	Published - Feb 1 2023

Keywords

COVID-19
SARS-CoV-2
immunocompromised hosts
vaccines

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciac652

Cite this

Karaba, A. H., Zhou, W., Li, S., Aytenfisu, T. Y., Johnston, T. S., Akinde, O., Eby, Y., Abedon, A. T., Alejo, J. L., Qin, C. X., Thompson, E. A., Garonzik, J., Blankson, J. N., Cox, A. L., Bailey, J. R., Klein, S. L., Pekosz, A., Segev, D., Tobian, A. A. R., & Werbel, W. A. (2023). Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients. Clinical Infectious Diseases, 76(3), E495-E498. https://doi.org/10.1093/cid/ciac652

Karaba, AH , Zhou, W, Li, S, Aytenfisu, TY, Johnston, TS, Akinde, O, Eby, Y, Abedon, AT, Alejo, JL, Qin, CX, Thompson, EA, Garonzik, J, Blankson, JN , Cox, AL , Bailey, JR , Klein, SL , Pekosz, A, Segev, D, Tobian, AAR & Werbel, WA 2023, 'Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients', Clinical Infectious Diseases, vol. 76, no. 3, pp. E495-E498. https://doi.org/10.1093/cid/ciac652

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abstract = "Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of preexisting antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in SOTRs.",

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AU - Zhou, Weiqiang

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AU - Aytenfisu, Tihitina Y.

AU - Johnston, Trevor S.

AU - Akinde, Olivia

AU - Eby, Yolanda

AU - Abedon, Aura T.

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AU - Blankson, Joel N.

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AU - Klein, Sabra L.

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AU - Segev, Dorry

AU - Tobian, Aaron A.R.

AU - Werbel, William A.

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Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients

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