Impact of prior treatment on feasibility and outcomes of Zenker's peroral endoscopic myotomy (Z-POEM)

Omid Sanaei, Yervant Ichkhanian, Oscar V.Hernández Mondragón, Jose Nieto, Arunkumar Krishnan, Marcel Tantau, Alina Tantau, Pankaj N. Desai, Gregory G. Ginsberg, Monica Saumoy, Ameya Deshmukh, Mikhail Attaar, Jad Farha, Manol Jovani, Sarah S. Al-Ghamdi, Michael Ujiki, Mouen A. Khashab

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background Zenker's peroral endoscopic myotomy (Z-POEM) is a novel procedure for the management of symptomatic Zenker's diverticulum. This study aims to report the technical feasibility and outcomes of Z-POEM in the management of Zenker's diverticulum after prior failed interventions. Methods Patients with persistent or recurrent symptoms after prior endoscopic and/or surgical intervention for Zenker's diverticulum were retrospectively included. The primary outcome was clinical success, defined as complete or near complete resolution of dysphagia (dysphagia score of 0 or 1) without the need for repeat endoscopic or surgical intervention during follow-up. Results Z-POEM was technically successful in 30/32 patients (93.8%). Clinical success was achieved in 29/30 patients (96.7%), and Z-POEM significantly reduced the median (interquartile range [IQR]) dysphagia score of patients from 2 (1-2) to 0 (0) (P<0.001) over a median duration of follow up of 166 days (IQR 39-566). Four patients (12.5%) had adverse events (two inadvertent mucosotomies and two leaks found on post-procedural esophagrams). Conclusion Z-POEM is feasible, safe, and effective in the majority of patients with recurrent symptoms after prior surgical or endoscopic interventions.

Original languageEnglish (US)
Pages (from-to)722-726
Number of pages5
Issue number7
StatePublished - Jul 1 2021

ASJC Scopus subject areas

  • Gastroenterology


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