Abstract
The effect of pregnancy and lactation on GABA(A) receptor and central- and peripheral-type benzodiazepine receptors (CBR and PBR, respectively) was studied in female Sprague-Dawley rats. Pregnancy was associated with increased CBR density (on day 19) in the hippocampus and with decreased [3H]Ro 15-1788-specific binding in the hypothalamus during pregnancy and lactation. A similar decrease in [3H]PK 11195-speciric binding was observed in the hypothalamus and pituitary. An increase in PBR density in the ovary and uterus was observed during pregnancy, while adrenal PBR density was down-regulated during pregnancy and lactation. It seems that the hormonal changes occurring during pregnancy and lactation play a role in the regulation of CBR and PBR in discrete tissues.
Original language | English (US) |
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Pages (from-to) | 307-314 |
Number of pages | 8 |
Journal | Brain research |
Volume | 752 |
Issue number | 1-2 |
DOIs | |
State | Published - Mar 28 1997 |
Keywords
- GABA(A) receptor
- central-type benzodiazepine receptor
- lactation
- peripheral-type benzodiazepine receptor
- pregnancy
- progesterone
- prolactin
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology