Impact of pregnancy and lactation on GABA(A) receptor and central-type and peripheral-type benzodiazepine receptors

Ronit Weizman; Efrat Dagan; Solomon H. Snyder; Moshe Gavish

doi:10.1016/S0006-8993(96)01489-8

Impact of pregnancy and lactation on GABA(A) receptor and central-type and peripheral-type benzodiazepine receptors

Ronit Weizman, Efrat Dagan, Solomon H. Snyder, Moshe Gavish

School of Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The effect of pregnancy and lactation on GABA(A) receptor and central- and peripheral-type benzodiazepine receptors (CBR and PBR, respectively) was studied in female Sprague-Dawley rats. Pregnancy was associated with increased CBR density (on day 19) in the hippocampus and with decreased [³H]Ro 15-1788-specific binding in the hypothalamus during pregnancy and lactation. A similar decrease in [³H]PK 11195-speciric binding was observed in the hypothalamus and pituitary. An increase in PBR density in the ovary and uterus was observed during pregnancy, while adrenal PBR density was down-regulated during pregnancy and lactation. It seems that the hormonal changes occurring during pregnancy and lactation play a role in the regulation of CBR and PBR in discrete tissues.

Original language	English (US)
Pages (from-to)	307-314
Number of pages	8
Journal	Brain research
Volume	752
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(96)01489-8
State	Published - Mar 28 1997

Keywords

GABA(A) receptor
central-type benzodiazepine receptor
lactation
peripheral-type benzodiazepine receptor
pregnancy
progesterone
prolactin

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(96)01489-8

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title = "Impact of pregnancy and lactation on GABA(A) receptor and central-type and peripheral-type benzodiazepine receptors",

abstract = "The effect of pregnancy and lactation on GABA(A) receptor and central- and peripheral-type benzodiazepine receptors (CBR and PBR, respectively) was studied in female Sprague-Dawley rats. Pregnancy was associated with increased CBR density (on day 19) in the hippocampus and with decreased [3H]Ro 15-1788-specific binding in the hypothalamus during pregnancy and lactation. A similar decrease in [3H]PK 11195-speciric binding was observed in the hypothalamus and pituitary. An increase in PBR density in the ovary and uterus was observed during pregnancy, while adrenal PBR density was down-regulated during pregnancy and lactation. It seems that the hormonal changes occurring during pregnancy and lactation play a role in the regulation of CBR and PBR in discrete tissues.",

keywords = "GABA(A) receptor, central-type benzodiazepine receptor, lactation, peripheral-type benzodiazepine receptor, pregnancy, progesterone, prolactin",

author = "Ronit Weizman and Efrat Dagan and Snyder, {Solomon H.} and Moshe Gavish",

note = "Funding Information: This study was supportedin part by Grant 91-00146(t o M.G. and S.H.S.) from the U.S.-Israel BinationalS cience Foundation.W e thank Miss Ruth Singer for typing and editing lhz manuscript.",

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AU - Weizman, Ronit

AU - Dagan, Efrat

AU - Snyder, Solomon H.

AU - Gavish, Moshe

N1 - Funding Information: This study was supportedin part by Grant 91-00146(t o M.G. and S.H.S.) from the U.S.-Israel BinationalS cience Foundation.W e thank Miss Ruth Singer for typing and editing lhz manuscript.

PY - 1997/3/28

Y1 - 1997/3/28

N2 - The effect of pregnancy and lactation on GABA(A) receptor and central- and peripheral-type benzodiazepine receptors (CBR and PBR, respectively) was studied in female Sprague-Dawley rats. Pregnancy was associated with increased CBR density (on day 19) in the hippocampus and with decreased [3H]Ro 15-1788-specific binding in the hypothalamus during pregnancy and lactation. A similar decrease in [3H]PK 11195-speciric binding was observed in the hypothalamus and pituitary. An increase in PBR density in the ovary and uterus was observed during pregnancy, while adrenal PBR density was down-regulated during pregnancy and lactation. It seems that the hormonal changes occurring during pregnancy and lactation play a role in the regulation of CBR and PBR in discrete tissues.

AB - The effect of pregnancy and lactation on GABA(A) receptor and central- and peripheral-type benzodiazepine receptors (CBR and PBR, respectively) was studied in female Sprague-Dawley rats. Pregnancy was associated with increased CBR density (on day 19) in the hippocampus and with decreased [3H]Ro 15-1788-specific binding in the hypothalamus during pregnancy and lactation. A similar decrease in [3H]PK 11195-speciric binding was observed in the hypothalamus and pituitary. An increase in PBR density in the ovary and uterus was observed during pregnancy, while adrenal PBR density was down-regulated during pregnancy and lactation. It seems that the hormonal changes occurring during pregnancy and lactation play a role in the regulation of CBR and PBR in discrete tissues.

KW - GABA(A) receptor

KW - central-type benzodiazepine receptor

KW - lactation

KW - peripheral-type benzodiazepine receptor

KW - pregnancy

KW - progesterone

KW - prolactin

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Impact of pregnancy and lactation on GABA(A) receptor and central-type and peripheral-type benzodiazepine receptors

Abstract

Keywords

ASJC Scopus subject areas

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