Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases

Luis M.F. Gonzalez; Rodrigo M. Brindeiro; Renato S. Aguiar; Helena S. Pereira; Celina M. Abreu; Marcelo A. Soares; Amilcar Tanuri

doi:10.1128/AAC.48.9.3552-3555.2004

Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases

Luis M.F. Gonzalez, Rodrigo M. Brindeiro, Renato S. Aguiar, Helena S. Pereira, Celina M. Abreu, Marcelo A. Soares, Amilcar Tanuri

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Human immunodeficiency virus type 1 subtype B and C proteases were manipulated to contain 90M, 88D, or 89L, and their in vitro biological properties were studied. We showed that D30N has significantly more impact in subtype C than in subtype B counterparts, accounting for the reported low prevalence of this mutation in patients failing nelfanavir-based regimens.

Original language	English (US)
Pages (from-to)	3552-3555
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	48
Issue number	9
DOIs	https://doi.org/10.1128/AAC.48.9.3552-3555.2004
State	Published - Sep 2004
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.48.9.3552-3555.2004

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Gonzalez, L. M. F., Brindeiro, R. M., Aguiar, R. S., Pereira, H. S., Abreu, C. M., Soares, M. A., & Tanuri, A. (2004). Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases. Antimicrobial agents and chemotherapy, 48(9), 3552-3555. https://doi.org/10.1128/AAC.48.9.3552-3555.2004

Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases. / Gonzalez, Luis M.F.; Brindeiro, Rodrigo M.; Aguiar, Renato S. et al.
In: Antimicrobial agents and chemotherapy, Vol. 48, No. 9, 09.2004, p. 3552-3555.

Research output: Contribution to journal › Article › peer-review

Gonzalez, LMF, Brindeiro, RM, Aguiar, RS, Pereira, HS, Abreu, CM, Soares, MA & Tanuri, A 2004, 'Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases', Antimicrobial agents and chemotherapy, vol. 48, no. 9, pp. 3552-3555. https://doi.org/10.1128/AAC.48.9.3552-3555.2004

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abstract = "Human immunodeficiency virus type 1 subtype B and C proteases were manipulated to contain 90M, 88D, or 89L, and their in vitro biological properties were studied. We showed that D30N has significantly more impact in subtype C than in subtype B counterparts, accounting for the reported low prevalence of this mutation in patients failing nelfanavir-based regimens.",

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AU - Pereira, Helena S.

AU - Abreu, Celina M.

AU - Soares, Marcelo A.

AU - Tanuri, Amilcar

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Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases

Abstract

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