Impact of a combined intravenous/intra-arterial approach in octogenarians

Mikael Mazighi, Julien Labreuche, Elena Meseguer, Jean Michel Serfaty, Jean Pierre Laissy, Philippa C. Lavallée, Lucie Cabrejo, Céline Guidoux, Bertrand Lapergue, Isabelle F. Klein, Jean Marc Olivot, Halim Abboud, Olivier Simon, Elisabeth Schouman-Claeys, Pierre Amarenco

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background: Intravenous (IV) alteplase is not currently recommended in octogenarian patients, and the benefit/risk ratio of endovascular (intra-arterial, IA) therapy remains to be determined. The aim of this study was to determine the impact of a combined IV-IA approach in octogenarians. Methods: From a single-centre interventional study, we report age-specific outcomes of patients treated by a combined IV-IA thrombolytic approach. Patients ≥80 years with documented arterial occlusion treated by conventional IV thrombolysis constituted the control group. Results: Among 84 patients treated by the IV-IA approach, those ≥80 years (n = 25) had a similar rate of early neurological improvement to that of patients

Original languageEnglish (US)
Pages (from-to)559-565
Number of pages7
JournalCerebrovascular Diseases
Issue number6
StatePublished - May 2011
Externally publishedYes


  • Alteplase
  • Combined intravenous/intra-arterial approach
  • Octogenarians
  • Recombinant tissue plasminogen activator

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Impact of a combined intravenous/intra-arterial approach in octogenarians'. Together they form a unique fingerprint.

Cite this