Impact of a combined intravenous/intra-arterial approach in octogenarians

Mikael Mazighi; Julien Labreuche; Elena Meseguer; Jean Michel Serfaty; Jean Pierre Laissy; Philippa C. Lavallée; Lucie Cabrejo; Céline Guidoux; Bertrand Lapergue; Isabelle F. Klein; Jean Marc Olivot; Halim Abboud; Olivier Simon; Elisabeth Schouman-Claeys; Pierre Amarenco

doi:10.1159/000324626

Impact of a combined intravenous/intra-arterial approach in octogenarians

Mikael Mazighi, Julien Labreuche, Elena Meseguer, Jean Michel Serfaty, Jean Pierre Laissy, Philippa C. Lavallée, Lucie Cabrejo, Céline Guidoux, Bertrand Lapergue, Isabelle F. Klein, Jean Marc Olivot, Halim Abboud, Olivier Simon, Elisabeth Schouman-Claeys, Pierre Amarenco

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background: Intravenous (IV) alteplase is not currently recommended in octogenarian patients, and the benefit/risk ratio of endovascular (intra-arterial, IA) therapy remains to be determined. The aim of this study was to determine the impact of a combined IV-IA approach in octogenarians. Methods: From a single-centre interventional study, we report age-specific outcomes of patients treated by a combined IV-IA thrombolytic approach. Patients ≥80 years with documented arterial occlusion treated by conventional IV thrombolysis constituted the control group. Results: Among 84 patients treated by the IV-IA approach, those ≥80 years (n = 25) had a similar rate of early neurological improvement to that of patients

Original language	English (US)
Pages (from-to)	559-565
Number of pages	7
Journal	Cerebrovascular Diseases
Volume	31
Issue number	6
DOIs	https://doi.org/10.1159/000324626
State	Published - May 2011
Externally published	Yes

Keywords

Alteplase
Combined intravenous/intra-arterial approach
Octogenarians
Recombinant tissue plasminogen activator

ASJC Scopus subject areas

Clinical Neurology
Neurology
Cardiology and Cardiovascular Medicine

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10.1159/000324626

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Mazighi, M., Labreuche, J., Meseguer, E., Serfaty, J. M., Laissy, J. P., Lavallée, P. C., Cabrejo, L., Guidoux, C., Lapergue, B., Klein, I. F., Olivot, J. M., Abboud, H., Simon, O., Schouman-Claeys, E., & Amarenco, P. (2011). Impact of a combined intravenous/intra-arterial approach in octogenarians. Cerebrovascular Diseases, 31(6), 559-565. https://doi.org/10.1159/000324626

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title = "Impact of a combined intravenous/intra-arterial approach in octogenarians",

abstract = "Background: Intravenous (IV) alteplase is not currently recommended in octogenarian patients, and the benefit/risk ratio of endovascular (intra-arterial, IA) therapy remains to be determined. The aim of this study was to determine the impact of a combined IV-IA approach in octogenarians. Methods: From a single-centre interventional study, we report age-specific outcomes of patients treated by a combined IV-IA thrombolytic approach. Patients ≥80 years with documented arterial occlusion treated by conventional IV thrombolysis constituted the control group. Results: Among 84 patients treated by the IV-IA approach, those ≥80 years (n = 25) had a similar rate of early neurological improvement to that of patients ",

keywords = "Alteplase, Combined intravenous/intra-arterial approach, Octogenarians, Recombinant tissue plasminogen activator",

author = "Mikael Mazighi and Julien Labreuche and Elena Meseguer and Serfaty, {Jean Michel} and Laissy, {Jean Pierre} and Lavall{\'e}e, {Philippa C.} and Lucie Cabrejo and C{\'e}line Guidoux and Bertrand Lapergue and Klein, {Isabelle F.} and Olivot, {Jean Marc} and Halim Abboud and Olivier Simon and Elisabeth Schouman-Claeys and Pierre Amarenco",

year = "2011",

month = may,

doi = "10.1159/000324626",

language = "English (US)",

volume = "31",

pages = "559--565",

journal = "Cerebrovascular Diseases",

issn = "1015-9770",

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TY - JOUR

T1 - Impact of a combined intravenous/intra-arterial approach in octogenarians

AU - Mazighi, Mikael

AU - Labreuche, Julien

AU - Meseguer, Elena

AU - Serfaty, Jean Michel

AU - Laissy, Jean Pierre

AU - Lavallée, Philippa C.

AU - Cabrejo, Lucie

AU - Guidoux, Céline

AU - Lapergue, Bertrand

AU - Klein, Isabelle F.

AU - Olivot, Jean Marc

AU - Abboud, Halim

AU - Simon, Olivier

AU - Schouman-Claeys, Elisabeth

AU - Amarenco, Pierre

PY - 2011/5

Y1 - 2011/5

N2 - Background: Intravenous (IV) alteplase is not currently recommended in octogenarian patients, and the benefit/risk ratio of endovascular (intra-arterial, IA) therapy remains to be determined. The aim of this study was to determine the impact of a combined IV-IA approach in octogenarians. Methods: From a single-centre interventional study, we report age-specific outcomes of patients treated by a combined IV-IA thrombolytic approach. Patients ≥80 years with documented arterial occlusion treated by conventional IV thrombolysis constituted the control group. Results: Among 84 patients treated by the IV-IA approach, those ≥80 years (n = 25) had a similar rate of early neurological improvement to that of patients

AB - Background: Intravenous (IV) alteplase is not currently recommended in octogenarian patients, and the benefit/risk ratio of endovascular (intra-arterial, IA) therapy remains to be determined. The aim of this study was to determine the impact of a combined IV-IA approach in octogenarians. Methods: From a single-centre interventional study, we report age-specific outcomes of patients treated by a combined IV-IA thrombolytic approach. Patients ≥80 years with documented arterial occlusion treated by conventional IV thrombolysis constituted the control group. Results: Among 84 patients treated by the IV-IA approach, those ≥80 years (n = 25) had a similar rate of early neurological improvement to that of patients

KW - Alteplase

KW - Combined intravenous/intra-arterial approach

KW - Octogenarians

KW - Recombinant tissue plasminogen activator

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Impact of a combined intravenous/intra-arterial approach in octogenarians

Abstract

Keywords

ASJC Scopus subject areas

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