Abstract
Human papillomaviruses are associated with a broad range of carcinomas, including cervical cancer. Although the delivery of immunogenic tumor-associated antigens represents a promising approach in the treatment of these malignancies, the imposition of T cell tolerance poses a significant challenge in this endeavor. The purpose of this review is to discuss T cell tolerance and the role of T cell costimulation in the immunotherapy of HPV-associated malignancies.
Original language | English (US) |
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Journal | Frontiers in bioscience : a journal and virtual library |
Volume | 7 |
State | Published - 2002 |
Externally published | Yes |