TY - JOUR
T1 - Immunosuppressive Effects of Selected Metabolic Inhibitors in Vivo and in Vitro
AU - Rose, Noel R.
AU - Haber, Judith A.
AU - Calabresi, Paul
N1 - Funding Information:
in Vivo and in Vitro ∗ Rose Noel R. 1 Haber Judith A. 2 Calabresi Paul 3 Institut de Biochimie et Institut Suisse de Recherches Expérimentales sur le Cancer, Lausanne, Switzerland ∗ These studies were supported in part by U. S. Public Health Service Research Grants CA-05944 and CA-05203, and funds from the Swiss National Foundation. 1 Supported in part by a Public Health Service Special Fellowship AI-3023 from the National Institute of Allergy and Infectious Diseases. Permanent address: Department of Microbiology, State University of New York at Buffalo. 2 NASA Predoctoral Fellow. Present address: Department of Microbiology, School of Medicine, State University of New York at Buffalo. 3 Burroughs Wellcome Scholar in Clinical Pharmacology. Work performed under tenure of an Eleanor Roosevelt Cancer Fellowship of the American Cancer Society. Present address: Division of Bio-Medical Sciences, Brown University and Department of Medicine, Roger Williams General Hospitals, Providence, Rhode Island. 8-9 1968 128 4 1121 1128
PY - 1968/9/8
Y1 - 1968/9/8
N2 - Actinomycin D, puromycin, 6-mercaptopurine, and cytosine arabinoside were shown to decrease the number of plaque-forming units upon in vitro incubation with suspensions of spleen cells taken from sheep-cell immunized mice. Under similar conditions, 5-iodo-2′-deoxyuridine, 5-bromo-2′-deoxyuridine, azauridine, and chloramphenicol had no effect. Administered in vivo, 6-mercaptopurine, cytosine arabinoside, and chloramphenicol all suppressed plaque production. In the case of the latter two antimetabolites, serum antibody titers remained unaffected by the dosages given.
AB - Actinomycin D, puromycin, 6-mercaptopurine, and cytosine arabinoside were shown to decrease the number of plaque-forming units upon in vitro incubation with suspensions of spleen cells taken from sheep-cell immunized mice. Under similar conditions, 5-iodo-2′-deoxyuridine, 5-bromo-2′-deoxyuridine, azauridine, and chloramphenicol had no effect. Administered in vivo, 6-mercaptopurine, cytosine arabinoside, and chloramphenicol all suppressed plaque production. In the case of the latter two antimetabolites, serum antibody titers remained unaffected by the dosages given.
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U2 - 10.3181/00379727-128-33210
DO - 10.3181/00379727-128-33210
M3 - Article
AN - SCOPUS:84912287139
SN - 0037-9727
VL - 128
SP - 1121
EP - 1128
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 4
ER -