Immunoregulatory functions of mTOR inhibition

Angus W. Thomson, Heth R. Turnquist, Giorgio Raimondi

Research output: Contribution to journalReview articlepeer-review

595 Scopus citations


The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of growth factor-induced T cell proliferation. However, it is now evident that the serine/threonine protein kinase mammalian target of rapamycin (mTOR) has an important role in the modulation of both innate and adaptive immune responses. mTOR regulates diverse functions of professional antigen-presenting cells, such as dendritic cells (DCs), and has important roles in the activation of effector T cells and the function and proliferation of regulatory T cells. In this Review, we discuss our current understanding of the mTOR pathway and the consequences of mTOR inhibition, both in DCs and T cells, including new data on the regulation of forkhead box P3 expression.

Original languageEnglish (US)
Pages (from-to)324-337
Number of pages14
JournalNature Reviews Immunology
Issue number5
StatePublished - May 2009
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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