TY - JOUR
T1 - Immunoreactive neurotensin levels in pancreas
T2 - Elevation in diabetic rats and mice
AU - Fernstrom, Madelyn Hirsch
AU - Mirski, Marek A.Z.
AU - Carraway, Robert E.
AU - Leeman, Susan E.
N1 - Funding Information:
From the Department of Physiology and Laboratory of Human Reproduction and Reproductive Biology, Harvard Medical School. Boston, Massachusetts. Supported in part by the Narional Institute of Health (S.E.L.) and the Juvenile Diabetes Foundation (M.H.F.). Received for publication October 8. 1980. Address reprint requests to Massachuserrs tnstitute of Technology, Dept. of Nutrition and Food Science. Building 56-135, 77 Massachusetts Avenue, Cambridge. Massachusetts 02139. (r 1981 by Grune & Stratton, Inc. 0026-0495/81/3009%0003$01.00/0
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1981/9
Y1 - 1981/9
N2 - Neurotensin levels in pancreas, but not other tissues, were increased in diabetic animals. The concentration of pancreatic immunoreactiveneurotensin was 138% higher in streptozotocin-diabetic rats, and 68% higher in genetically diabetic ( db db) mice as compared to their respective control animals. Daily administration of insulin (10-15 IU/kg) to diabetic rats completely reversed this effect, and pancreatic neurotensin levels in these animals returned to control values. These findings suggest that elevated levels of pancreatic neurotensin may contribute to some of the metabolic and hormonal disturbances occurring in diabetes.
AB - Neurotensin levels in pancreas, but not other tissues, were increased in diabetic animals. The concentration of pancreatic immunoreactiveneurotensin was 138% higher in streptozotocin-diabetic rats, and 68% higher in genetically diabetic ( db db) mice as compared to their respective control animals. Daily administration of insulin (10-15 IU/kg) to diabetic rats completely reversed this effect, and pancreatic neurotensin levels in these animals returned to control values. These findings suggest that elevated levels of pancreatic neurotensin may contribute to some of the metabolic and hormonal disturbances occurring in diabetes.
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U2 - 10.1016/0026-0495(81)90063-9
DO - 10.1016/0026-0495(81)90063-9
M3 - Article
C2 - 6455583
AN - SCOPUS:0019403346
SN - 0026-0495
VL - 30
SP - 853
EP - 855
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 9
ER -