Immunophilin Ligands

Joseph P. Steiner; N. J. Haughey

doi:10.1016/B978-0-12-374105-9.00254-9

Immunophilin Ligands

Joseph P. Steiner, N. J. Haughey

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Immunophilin ligands are potent, neuroprotective molecules with high selectivity for multiple FKBPs. They protect against excitotoxic lesions of hippocampal and motor neurons, as well as lesions of the nigral striatal dopaminergic pathway. They stimulate functional regrowth of damaged sciatic, cortical cholinergic, dopamine and 5-HT neurons. There may be multiple mechanisms of action to account for these neurotrophic activities.

Original language	English (US)
Title of host publication	Encyclopedia of Movement Disorders, Three-Volume Set
Publisher	Elsevier
Pages	V2-66-V2-68
ISBN (Electronic)	9780123741059
DOIs	https://doi.org/10.1016/B978-0-12-374105-9.00254-9
State	Published - Jan 1 2010

Keywords

Calcineurin
Cyclophilins
Dopaminergic neurons
FK1706
FK506
FK506 binding proteins
GPI1046
Immunophilin
Motor neurons
Neuroprotective
Neuroregenerative
Neurotrophic
Sensory neurons
V-10367

ASJC Scopus subject areas

General Medicine
General Neuroscience

Access to Document

10.1016/B978-0-12-374105-9.00254-9

Cite this

@inbook{c15b99d061e74e7daaa630b2482ba39b,

title = "Immunophilin Ligands",

abstract = "Immunophilin ligands are potent, neuroprotective molecules with high selectivity for multiple FKBPs. They protect against excitotoxic lesions of hippocampal and motor neurons, as well as lesions of the nigral striatal dopaminergic pathway. They stimulate functional regrowth of damaged sciatic, cortical cholinergic, dopamine and 5-HT neurons. There may be multiple mechanisms of action to account for these neurotrophic activities.",

keywords = "Calcineurin, Cyclophilins, Dopaminergic neurons, FK1706, FK506, FK506 binding proteins, GPI1046, Immunophilin, Motor neurons, Neuroprotective, Neuroregenerative, Neurotrophic, Sensory neurons, V-10367",

author = "Steiner, {Joseph P.} and Haughey, {N. J.}",

year = "2010",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-374105-9.00254-9",

language = "English (US)",

pages = "V2--66--V2--68",

booktitle = "Encyclopedia of Movement Disorders, Three-Volume Set",

publisher = "Elsevier",

}

TY - CHAP

T1 - Immunophilin Ligands

AU - Steiner, Joseph P.

AU - Haughey, N. J.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Immunophilin ligands are potent, neuroprotective molecules with high selectivity for multiple FKBPs. They protect against excitotoxic lesions of hippocampal and motor neurons, as well as lesions of the nigral striatal dopaminergic pathway. They stimulate functional regrowth of damaged sciatic, cortical cholinergic, dopamine and 5-HT neurons. There may be multiple mechanisms of action to account for these neurotrophic activities.

AB - Immunophilin ligands are potent, neuroprotective molecules with high selectivity for multiple FKBPs. They protect against excitotoxic lesions of hippocampal and motor neurons, as well as lesions of the nigral striatal dopaminergic pathway. They stimulate functional regrowth of damaged sciatic, cortical cholinergic, dopamine and 5-HT neurons. There may be multiple mechanisms of action to account for these neurotrophic activities.

KW - Calcineurin

KW - Cyclophilins

KW - Dopaminergic neurons

KW - FK1706

KW - FK506

KW - FK506 binding proteins

KW - GPI1046

KW - Immunophilin

KW - Motor neurons

KW - Neuroprotective

KW - Neuroregenerative

KW - Neurotrophic

KW - Sensory neurons

KW - V-10367

UR - http://www.scopus.com/inward/record.url?scp=85184535510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85184535510&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374105-9.00254-9

DO - 10.1016/B978-0-12-374105-9.00254-9

M3 - Chapter

AN - SCOPUS:85184535510

SP - V2-66-V2-68

BT - Encyclopedia of Movement Disorders, Three-Volume Set

PB - Elsevier

ER -

Immunophilin Ligands

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this