Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome: A volume in Woodhead Publishing Series in Biomaterials

Stephen F. Badylak, Jennifer H. Elisseeff

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert” immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines.

Original languageEnglish (US)
Title of host publicationImmunomodulatory Biomaterials
Subtitle of host publicationRegulating the Immune Response with Biomaterials to Affect Clinical Outcome
PublisherElsevier
Pages1-279
Number of pages279
ISBN (Electronic)9780128214404
DOIs
StatePublished - Jan 1 2021

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology

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