Immunology of corneal allograft rejection: HLA-DR antigens on human corneal cells

E. Young; W. J. Stark; R. A. Prendergast

Immunology of corneal allograft rejection: HLA-DR antigens on human corneal cells

E. Young, W. J. Stark, R. A. Prendergast

Research output: Contribution to journal › Article › peer-review

Abstract

Human stromal and endothelial cultures were established from corneas obtained from the Maryland Eye Bank. Cultures were incubated in the presence of human gamma interferon for 4 days, trypsinized, washed, and then stained with a monoclonal reagent specific for human Class II (HLA-DR) antigens. Under these conditions, 100% of human corneal endothelial cells and 40 to 70% human corneal stromal cells expressed HLA-DR antigens.

Original language	English (US)
Pages (from-to)	571-574
Number of pages	4
Journal	Investigative Ophthalmology and Visual Science
Volume	26
Issue number	4
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Cite this

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title = "Immunology of corneal allograft rejection: HLA-DR antigens on human corneal cells",

abstract = "Human stromal and endothelial cultures were established from corneas obtained from the Maryland Eye Bank. Cultures were incubated in the presence of human gamma interferon for 4 days, trypsinized, washed, and then stained with a monoclonal reagent specific for human Class II (HLA-DR) antigens. Under these conditions, 100% of human corneal endothelial cells and 40 to 70% human corneal stromal cells expressed HLA-DR antigens.",

author = "E. Young and Stark, {W. J.} and Prendergast, {R. A.}",

year = "1985",

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AU - Stark, W. J.

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PY - 1985

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N2 - Human stromal and endothelial cultures were established from corneas obtained from the Maryland Eye Bank. Cultures were incubated in the presence of human gamma interferon for 4 days, trypsinized, washed, and then stained with a monoclonal reagent specific for human Class II (HLA-DR) antigens. Under these conditions, 100% of human corneal endothelial cells and 40 to 70% human corneal stromal cells expressed HLA-DR antigens.

AB - Human stromal and endothelial cultures were established from corneas obtained from the Maryland Eye Bank. Cultures were incubated in the presence of human gamma interferon for 4 days, trypsinized, washed, and then stained with a monoclonal reagent specific for human Class II (HLA-DR) antigens. Under these conditions, 100% of human corneal endothelial cells and 40 to 70% human corneal stromal cells expressed HLA-DR antigens.

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Immunology of corneal allograft rejection: HLA-DR antigens on human corneal cells

Abstract

ASJC Scopus subject areas

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