Immunology of corneal allograft rejection: HLA-DR antigens on human corneal cells

E. Young, W. J. Stark, R. A. Prendergast

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Human stromal and endothelial cultures were established from corneas obtained from the Maryland Eye Bank. Cultures were incubated in the presence of human gamma interferon for 4 days, trypsinized, washed, and then stained with a monoclonal reagent specific for human Class II (HLA-DR) antigens. Under these conditions, 100% of human corneal endothelial cells and 40 to 70% human corneal stromal cells expressed HLA-DR antigens.

Original languageEnglish (US)
Pages (from-to)571-574
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Volume26
Issue number4
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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