TY - JOUR
T1 - Immunologic studies of rabies vaccination-induced guillain-barré syndrome
AU - Hemachudha, Thiravat
AU - Griffin, Diane E.
AU - Chen, Winston W.
AU - Johnson, Richard T.
PY - 1988/3
Y1 - 1988/3
N2 - Patients with Guillain-Barre syndrome (GBS) induced by rabies vaccines prepared from either suckling mouse brain (SMB) or mature sheep brain (Semple vaccine) and patients with sporadic, idiopathic GBS were studied for antibody to myelin basic protein (MBP), P2 protein, and Schwann cells. Sera from all four Semple vaccine- and one of five SMB vaccine-induced GBS patients, but none of the sporadic GBS patients, had antibody to MBP. Sera from Semple vaccinees also had antibody to fixed, transformed Schwann cells, but similar amounts of antibody were found in sera from Semple vaccinees with CNS complications and with minor non-neurologic complications, suggesting that this antibody was not specifically linked to the development of polyneuritis. None of the sera had detectable antibody to P2 protein. We conclude that patients with GBS constitute a heterogeneous population and that different target antigens may serve as a focus for this presumed autoimmune disease.
AB - Patients with Guillain-Barre syndrome (GBS) induced by rabies vaccines prepared from either suckling mouse brain (SMB) or mature sheep brain (Semple vaccine) and patients with sporadic, idiopathic GBS were studied for antibody to myelin basic protein (MBP), P2 protein, and Schwann cells. Sera from all four Semple vaccine- and one of five SMB vaccine-induced GBS patients, but none of the sporadic GBS patients, had antibody to MBP. Sera from Semple vaccinees also had antibody to fixed, transformed Schwann cells, but similar amounts of antibody were found in sera from Semple vaccinees with CNS complications and with minor non-neurologic complications, suggesting that this antibody was not specifically linked to the development of polyneuritis. None of the sera had detectable antibody to P2 protein. We conclude that patients with GBS constitute a heterogeneous population and that different target antigens may serve as a focus for this presumed autoimmune disease.
UR - http://www.scopus.com/inward/record.url?scp=0023871517&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023871517&partnerID=8YFLogxK
U2 - 10.1212/wnl.38.3.375
DO - 10.1212/wnl.38.3.375
M3 - Article
C2 - 2450302
AN - SCOPUS:0023871517
SN - 0028-3878
VL - 38
SP - 375
EP - 378
JO - Neurology
JF - Neurology
IS - 3
ER -