Immunologic Parameters 2 Years after High-Titer Measles Immunization in Peruvian Childre

Neal A. Halsey, Maria Elena Léon, Brian Ward, Rosa Kanashiro, Herminio Hernandez, Susan Berry, Abraham Vaisberg, Joel Escamilla, Miguel Campos, Sicilia Bellomo, Veronica Azabache

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Immunization with high-titer measles vaccines has been associated with excess mortality in children 2–4 years after vaccination. In this study, immunologic parameters in 64 Peruvian children who had been immunized an average of 27 months earlier with high-titer vaccines were compared with parameters in 76 recipients of low-titer vaccines. Delayed-type hypersensitivity, lymphocyte phenotype distributions by flow cytometry, and lymphoproliferation after phytohemagglutinin (PHA) stimulation were assessed. High-titer recipients had smaller indurations to tetanus, diphtheria, and Proteus (P <.05) antigens, decreased PHA stimulation (P =.04), and a lower percentage of CD4+ lymphocytes (P =.04) than low-titer recipients. After adjustment for sex, concurrent illnesses, and other variables in regression analyses, high-titer recipients had a lower percentage of CD4+ lymphocytes (P =.025) and decreased lymphocyte proliferation to PHA (P =.058). These results may provide a clue to the pathogenesis of delayed excess mortality after high-titer measles vaccination in some developing countries.

Original languageEnglish (US)
Pages (from-to)1097-1104
Number of pages8
JournalJournal of Infectious Diseases
Volume168
Issue number5
DOIs
StatePublished - Dec 1993
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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