Immunologic monitoring during OKT3 intervention in cyclosporine-treated renal allograft recipients

W. J. Smith, J. F. Burdick, L. R. Pennington, G. M. Williams

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


When patients are treated with OKT3, the immediate effect is removal of circulating T cells and reversal of rejection. As T cells recover from this treatment and begin to repopulate the peripheral circulation, relative levels of helper and suppressor/cytotoxic cells, as measured by the OKT4/OKT8 ratio, may be indicative of the future outcome of the graft. This repopulation situation, which occurs only with complete removal of circulating T cells by monoclonal antibody, is different from the complex immune status of allograft recipients at other times. In this current study, repopulation with normal (>1.2) ratios carried a good prognosis for successful graft outcome. On the other hand, repopulation with a low ratio indicated that re-rejection could result in graft failure. Treatment of cyclosporine-treated recipients with OKT3 can be beneficial in clarifying the nature of graft dysfunction. In addition, such treatment may provide insight into the immunobiology of the allograft response.

Original languageEnglish (US)
Pages (from-to)756-757
Number of pages2
JournalTransplantation proceedings
Issue number4
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation


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