Immunologic defects in patients with chronic recurrent sinusitis: Diagnosis and management

Dharambir S. Sethi, Mark C. Loury, Jerry A. Winkelstein, Howard Lederman

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Twenty patients with chronic refractory sinusitis or rhinitis were identified to have immune defects on the basis of total immunoglobulin level, immunoglobulin G subclass, and vaccine response. Eight patients were immunoglobulin A deficient, five had low immunoglobulin levels with vaccine hyporesponse, and four had low immunoglobulin levels with normal vaccine responses. Three subjects showed isolated immunoglobulin G1 deficiency. Demographic variables such as age, sex, infection pattern, and any other related disorders were studied retrospectively, which may have contributed to the diagnosis. An immunologic screen was essential for the diagnosis of immunodeficiency in these patients. Treatment options included prophylactic antibiotics, management of associated allergies, functional endoscopic sinus surgery, and replacement therapy with immunoglobulin in selected patients.

Original languageEnglish (US)
Pages (from-to)242-247
Number of pages6
JournalOtolaryngology- Head and Neck Surgery
Issue number2
StatePublished - Feb 1995

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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