Immunohistochemical study of neurons containing corticotropin‐releasing factor in Alzheimer's disease

Richard E. Powers, Lary C. Walker, Errol B. De Souza, Wylie W. Vale, Robert G. Struble, Peter J. Whitehouse, Donald L. Price

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


In the brains of controls and individuals with Alzheimer's disease (AD), antisera to corticotropin‐releasing factor (CRF) were used to immunostain neurons and their processes. In AD, we identified abnormal CRF‐immunoreactive axons as well as neurites associated with deposits of amyloid in brain regions showing senile plaques. The number of immunoreactive fibers was decreased in individuals with AD. In contrast, CRF immunoreactivity was markedly increased in some neurons located within the paraventricular nucleus (PVN) of the hypothalamus. These findings support previous neurochemical studies indicating that certain CRF systems are affected in AD.

Original languageEnglish (US)
Pages (from-to)405-410
Number of pages6
Issue number5
StatePublished - 1987


  • Hypothalamus
  • Plaques
  • Senile

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


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