Immunogenetic analysis of human tuberculosis

Rebecca A. Cox, Marilyn Downs, Robert E. Neimes, Andre J. Ognibene, Toyoko S. Yamashita, Jerrold J. Ellner

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


An investigation was undertaken to determine if susceptibility and/or immune response to Mycobacterium tuberculosis was associated with histocompatible leukocyte antigen (HLA) phenotype frequencies of class I or II antigens. Comparisons of the HLA phenotypes of 51 Mexican-American patients with tuberculosis and 54 healthy subjects who differed in their skin-test reactivity to purified protein derivative (PPD) revealed that HLA-DR3 was significantly decreased in patients with tuberculosis, compared with healthy persons who were tuberculin skin-test positive. Although no association was observed between HLA phenotype and skin test reactivity to PPD in tuberculous patients, we did observe an increase in the HLA-A9-B40 phenotype in patients who manifested a strong in vitro proliferative response to PPD, whereas the HLA-B14-DR1 phenotype was increased in patients who exhibited a low proliferative response to this antigen.

Original languageEnglish (US)
Pages (from-to)1302-1308
Number of pages7
JournalJournal of Infectious Diseases
Issue number6
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health


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