Immunocytochemical localization of tetanus toxin to synapses of spinal cord

Donald L. Price, John W. Griffin

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


In this study, tetanus toxin was microinjected into the ventral horn of the spinal cord of rats, producing local tetanus. The toxin was localized by immunocytochemical methods. Reaction product was visualized within synaptic terminals, particularly those on the soma and dendrites of motor neurons. The distribution of staining terminals was similar to that of labeled synapses, visualized by autoradiography, after microinjection of either [125I]tetanus toxin or [3H]glycine, the latter a major inhibitor transmitter in the spinal cord.

Original languageEnglish (US)
Pages (from-to)149-155
Number of pages7
JournalNeuroscience Letters
Issue number2
StatePublished - May 6 1981

ASJC Scopus subject areas

  • Neuroscience(all)


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