TY - JOUR
T1 - Immunocompromised Patients with Protracted COVID-19
T2 - a Review of “Long Persisters”
AU - Dioverti, Veronica
AU - Salto-Alejandre, Sonsoles
AU - Haidar, Ghady
N1 - Funding Information:
V.D. has no disclosures or COI. S.S-A. is recipient of Fulbright Grant and IMFAHE Foundation Excellence Fellowship Grant. V.D. is an investigator for Regeneron Pharmaceuticals and AlloVir. G.H. is a recipient of research grants from Allovir, Karius, and AstraZeneca. G.H. also serves on the scientific advisory board of Karius.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Purpose of Review: Certain immunocompromised individuals are at risk for protracted COVID-19, in which SARS-CoV-2 leads to a chronic viral infection. However, the pathogenesis, diagnosis, and management of this phenomenon remain ill-defined. Recent Findings: Herein, we review key aspects of protracted SARS-CoV-2 infection in immunocompromised individuals, or the so-called long persisters, and describe the clinical presentation, risk factors, diagnosis, and treatment modalities of this condition, as well as intra-host viral evolution. Based on the available data, we also propose a framework of criteria with which to approach this syndrome. Summary: Protracted COVID-19 is an uncharacterized syndrome affecting patients with B-cell depletion; our proposed diagnostic approach and definitions will inform much needed future research.
AB - Purpose of Review: Certain immunocompromised individuals are at risk for protracted COVID-19, in which SARS-CoV-2 leads to a chronic viral infection. However, the pathogenesis, diagnosis, and management of this phenomenon remain ill-defined. Recent Findings: Herein, we review key aspects of protracted SARS-CoV-2 infection in immunocompromised individuals, or the so-called long persisters, and describe the clinical presentation, risk factors, diagnosis, and treatment modalities of this condition, as well as intra-host viral evolution. Based on the available data, we also propose a framework of criteria with which to approach this syndrome. Summary: Protracted COVID-19 is an uncharacterized syndrome affecting patients with B-cell depletion; our proposed diagnostic approach and definitions will inform much needed future research.
KW - COVID-19
KW - Immunocompromised
KW - Prolonged COVID-19
KW - Prolonged shedding
KW - SARS-CoV2
UR - http://www.scopus.com/inward/record.url?scp=85141659176&partnerID=8YFLogxK
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U2 - 10.1007/s40472-022-00385-y
DO - 10.1007/s40472-022-00385-y
M3 - Review article
C2 - 36407883
AN - SCOPUS:85141659176
SN - 2196-3029
VL - 9
SP - 209
EP - 218
JO - Current Transplantation Reports
JF - Current Transplantation Reports
IS - 4
ER -