Purified cholera toxoid is antigenic when given enterally and orally. Purified toxoid fails to provide protection against experimental challenge. Clinical cholera confers formidable protection against homologous or heterologous rechallenge. Failure to culture vibrios from intestinal fluid or stool of re-challenge volunteers suggests that the predominant immune mechanism is antibacterial rather than antitoxic.
|Number of pages
|Transactions of the Royal Society of Tropical Medicine and Hygiene
|Published - 1979
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Infectious Diseases