Immune-Mediated Necrotizing Myopathy (IMNM)

Brittany Adler; Lisa Christopher-Stine

doi:10.1007/978-3-030-15820-0_24

Immune-Mediated Necrotizing Myopathy (IMNM)

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Immune-mediated necrotizing myopathy (IMNM) is a distinct subset of the idiopathic inflammatory myopathies, characterized by proximal muscle weakness and muscle atrophy, markedly elevated CK levels, and myocyte necrosis with minimal inflammatory infiltrate on muscle biopsy. The two most common antibodies associated with IMNM are anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) and anti-signal recognition particle (anti-SRP), although in one-third of cases there are no identifiable autoantibodies. The greatest risk factor for anti-HMGCR myopathy is statin exposure, although it can occur independently of statins, especially in younger patients.

Original language	English (US)
Title of host publication	Managing Myositis
Subtitle of host publication	A Practical Guide
Publisher	Springer International Publishing
Pages	225-235
Number of pages	11
ISBN (Electronic)	9783030158200
ISBN (Print)	9783030158194
DOIs	https://doi.org/10.1007/978-3-030-15820-0_24
State	Published - Jan 1 2019

Keywords

3-Hydroxy-3-methylglutaryl-coenzyme A reductase
HMGCR
Immune-mediated necrotizing myopathy
Myositis
Necrotizing autoimmune myopathy
Signal recognition particle
SRP
Statin-induced myopathy

ASJC Scopus subject areas

General Medicine
General Neuroscience

Access to Document

10.1007/978-3-030-15820-0_24

Cite this

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title = "Immune-Mediated Necrotizing Myopathy (IMNM)",

abstract = "Immune-mediated necrotizing myopathy (IMNM) is a distinct subset of the idiopathic inflammatory myopathies, characterized by proximal muscle weakness and muscle atrophy, markedly elevated CK levels, and myocyte necrosis with minimal inflammatory infiltrate on muscle biopsy. The two most common antibodies associated with IMNM are anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) and anti-signal recognition particle (anti-SRP), although in one-third of cases there are no identifiable autoantibodies. The greatest risk factor for anti-HMGCR myopathy is statin exposure, although it can occur independently of statins, especially in younger patients.",

keywords = "3-Hydroxy-3-methylglutaryl-coenzyme A reductase, HMGCR, Immune-mediated necrotizing myopathy, Myositis, Necrotizing autoimmune myopathy, Signal recognition particle, SRP, Statin-induced myopathy",

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Y1 - 2019/1/1

N2 - Immune-mediated necrotizing myopathy (IMNM) is a distinct subset of the idiopathic inflammatory myopathies, characterized by proximal muscle weakness and muscle atrophy, markedly elevated CK levels, and myocyte necrosis with minimal inflammatory infiltrate on muscle biopsy. The two most common antibodies associated with IMNM are anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) and anti-signal recognition particle (anti-SRP), although in one-third of cases there are no identifiable autoantibodies. The greatest risk factor for anti-HMGCR myopathy is statin exposure, although it can occur independently of statins, especially in younger patients.

AB - Immune-mediated necrotizing myopathy (IMNM) is a distinct subset of the idiopathic inflammatory myopathies, characterized by proximal muscle weakness and muscle atrophy, markedly elevated CK levels, and myocyte necrosis with minimal inflammatory infiltrate on muscle biopsy. The two most common antibodies associated with IMNM are anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) and anti-signal recognition particle (anti-SRP), although in one-third of cases there are no identifiable autoantibodies. The greatest risk factor for anti-HMGCR myopathy is statin exposure, although it can occur independently of statins, especially in younger patients.

KW - 3-Hydroxy-3-methylglutaryl-coenzyme A reductase

KW - HMGCR

KW - Immune-mediated necrotizing myopathy

KW - Myositis

KW - Necrotizing autoimmune myopathy

KW - Signal recognition particle

KW - SRP

KW - Statin-induced myopathy

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M3 - Chapter

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SP - 225

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BT - Managing Myositis

PB - Springer International Publishing

ER -

Immune-Mediated Necrotizing Myopathy (IMNM)

Abstract

Keywords

ASJC Scopus subject areas

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