TY - JOUR
T1 - Immune Mechanisms in the Pathogenesis of Pulmonary Tuberculosis
AU - Dannenberg, Arthur M.
PY - 1989/3
Y1 - 1989/3
N2 - The pathogenesis of pulmonary tuberculosis and the beneficial and detrimental effects of the host's cell-mediated immune response in this disease are reviewed. Thbercle bacilli are hardy facultative intracellular pathogens that live and multiply in nonactivated macrophages. Before tubercle bacilli can be destroyed by macrophages, these cells must be activated by T lymphocytes and their lymphokines. Such activation is the essence of cell-mediated immunity. Cell-mediated immunity also has a detrimental component, called delayed-type hypersensitivity. This component causes caseous necrosis of host tissues whenever the bacillary antigens reach high levels. Such levels occur intracellularly in macrophages of highly susceptible hosts and extracellularly in liquefied caseous foci of resistant hosts. Vaccines containing antigens that create more cell-mediated immunity and less delayed-type hypersensitivity are greatly needed.
AB - The pathogenesis of pulmonary tuberculosis and the beneficial and detrimental effects of the host's cell-mediated immune response in this disease are reviewed. Thbercle bacilli are hardy facultative intracellular pathogens that live and multiply in nonactivated macrophages. Before tubercle bacilli can be destroyed by macrophages, these cells must be activated by T lymphocytes and their lymphokines. Such activation is the essence of cell-mediated immunity. Cell-mediated immunity also has a detrimental component, called delayed-type hypersensitivity. This component causes caseous necrosis of host tissues whenever the bacillary antigens reach high levels. Such levels occur intracellularly in macrophages of highly susceptible hosts and extracellularly in liquefied caseous foci of resistant hosts. Vaccines containing antigens that create more cell-mediated immunity and less delayed-type hypersensitivity are greatly needed.
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U2 - 10.1093/clinids/11.Supplement_2.S369
DO - 10.1093/clinids/11.Supplement_2.S369
M3 - Article
C2 - 2496453
AN - SCOPUS:0024634220
SN - 1058-4838
VL - 11
SP - S369-S378
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
ER -