Immediate (IgE-mediated) skin testing in the diagnosis of allergic disease

B. E. Chipps, R. C. Talamo, E. D. Mellits, M. D. Valentine

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Immediate (IgE-mediated) skin tests are widely used in the diagnosis of allergic diseases. Skin tests correlate well with more specialized studies (RAST, histamine release and provocation tests) in the diagnosis of allergic disease. Lack of standardization and quantitation of biologic potency of allergens make critical comparison of skin test results impossible. A survey of practicing allergists yielded widely divergent opinions concerning the effect of anti-allergic drugs on skin tests. The results of published studies indicate that only antihistamines cause significant depression of skin reactivity. Therefore, therapy for asthma may be continued while diagnostic skin testing is in progress, avoiding the possible morbidity associated with discontinuing pharmacologic therapy.

Original languageEnglish (US)
Pages (from-to)211-215
Number of pages5
JournalAnnals of allergy
Issue number4
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy


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