Abstract
This chapter describes the radiographic appearance and distribution of plexiformneurofibromas (PNs) in NF1. Although PNs are histologically benign tumors, they are thesource of significant morbidity including disfigurement, pain, functional impairment andthey can undergo malignant transformation. Identifying targeted agents that slow thegrowth or decrease the size of PNs is an area of intense research. Volumetric MRIanalysis of PNs is helpful in detecting treatment response and progression in these largeand complex shaped tumors with greater sensitivity compared to 1-dimensional or 2-dimensional measurements.
| Original language | English (US) |
|---|---|
| Title of host publication | Neurofibromatosis Type 1 |
| Subtitle of host publication | Symptoms, Treatment and Prognosis |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 23-40 |
| Number of pages | 18 |
| ISBN (Print) | 9781628081596 |
| State | Published - Dec 1 2013 |
ASJC Scopus subject areas
- General Medicine
- General Biochemistry, Genetics and Molecular Biology
Fingerprint
Dive into the research topics of 'Imaging of plexiform neurofibromas in neurofibromatosis type 1'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS